anti-TRF2 antibody (Telomeric Repeat Binding Factor 2) (C-Term)

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Antigen
Alternatives
Epitope
C-Term
(13), (11), (9), (8), (3), (3), (2), (2), (2), (2), (1), (1), (1)
Reactivity
Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Rat (Rattus), Xenopus laevis
(66), (16), (8), (3), (3), (2), (1)
Host
Rabbit
(46), (12), (12)
Clonality
Polyclonal
Conjugate
This TRF2 antibody is un-conjugated
(2), (2), (2), (2), (1), (1)
Application
Western Blotting (WB)
(57), (27), (20), (14), (9), (5), (3), (3), (3), (3), (3), (2), (1), (1), (1)
Pubmed 1 reference available
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Quantity 100 μg
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Immunogen Synthetic peptide directed towards the C terminal of human TERF2
Sequence TVEESEWVKA GVQKYGEGNW AAISKNYPFV NRTAVMIKDR WRTMKRLGMN
Predicted Reactivity African clawed frog : 100 %, Bovine : 100 %, Dog : 100 %, Guinea pig : 100 %, Horse : 100 %, Human : 100 %, Mouse : 100 %, Pig : 100 %, Rabbit : 100 %, Rat : 100 %
Characteristics This is a rabbit polyclonal antibody against TERF2. It was validated on Western Blot using a cell lysate as a positive control.
Purification Protein A purified
Alternative Name TERF2 (TERF2 Antibody Abstract)
Background TERF2 is a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic.This gene encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic.
Molecular Weight 55 kDa
Gene ID 7014
NCBI Accession NP_005643, NM_005652
UniProt Q15554
Research Area DNA/RNA, Cell Cycle, Enzymes
Pathways Cell Division Cycle, Telomere Maintenance
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 500 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-TRF2 antibody (Telomeric Repeat Binding Factor 2) (C-Term) (ABIN309587) anti-Telomeric Repeat Binding Factor 2 (TERF2) (C-Term) antibody
Background publications Etheridge, Compton, Barrientos et al.: "Tethering telomeric double- and single-stranded DNA-binding proteins inhibits telomere elongation." in: The Journal of biological chemistry, Vol. 283, Issue 11, pp. 6935-41, 2008 (PubMed).

Catalog No. ABIN309587

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