Telomeric Repeat Binding Factor 2 (TERF2) (C-Term) antibody

Details for Product No. ABIN309587
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Antigen
Synonyms TRF2, TRBF2, trf2, TERF2
Epitope
C-Term
(5), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Xenopus laevis, Cow (Bovine), Dog (Canine), Human
(38), (8), (4), (1), (1)
Host
Rabbit
(21), (11), (9)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(36), (13), (12), (10), (9), (7), (4), (3), (3), (2), (2), (2), (2), (1)
Pubmed 1 reference available
Catalog no. ABIN309587
Quantity 100 µg
Price
229.00 $   Plus shipping costs $45.00
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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Synthetic peptide directed towards the C terminal of human TERF2
Sequence TVEESEWVKAGVQKYGEGNWAAISKNYPFVNRTAVMIKDR WRTMKRLGMN
Predicted Reactivity African clawed frog : 100 %, Bovine : 100 %, Dog : 100 %, Guinea pig : 100 %, Horse : 100 %, Human : 100 %, Mouse : 100 %, Pig : 100 %, Rabbit : 100 %, Rat : 100 %
Characteristics This is a rabbit polyclonal antibody against TERF2. It was validated on Western Blot using a cell lysate as a positive control.
Purification Protein A purified
Alternative Name TERF2
Background TERF2 is a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic.This gene encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic.
Molecular Weight 55 kDa
Gene ID 7014
NCBI Accession NM_005652, NP_005643
UniProt Q15554
Research Area DNA/RNA, Cell Cycle, Enzymes
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 500 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Background publications Etheridge, Compton, Barrientos et al.: "Tethering telomeric double- and single-stranded DNA-binding proteins inhibits telomere elongation." in: The Journal of biological chemistry, Vol. 283, Issue 11, pp. 6935-41, 2008 (PubMed).

Hosts (21), (11), (9)
Reactivities (38), (8), (4), (1), (1)
Applications (36), (13), (12), (10), (9), (7), (4), (3), (3), (2), (2), (2), (2), (1)
Conjugates (1), (1), (1), (1), (1)
Epitopes (5), (2), (2), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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