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LKB1 antibody (serine/threonine Kinase 11) (N-Term)

Details for Product anti-STK11 Antibody No. ABIN310216, Supplier: Login to see New
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Antigen
Alternatives
Epitope
N-Term
(55), (47), (30), (28), (24), (15), (12), (12), (12), (8), (8), (7), (6), (5), (4), (4), (4), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Chicken, Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Rat (Rattus), Xenopus laevis, Zebrafish (Danio rerio)
(288), (163), (86), (7), (3), (3), (2), (2), (2), (1)
Host
Rabbit
(288), (21)
Clonality
Polyclonal
Conjugate
This LKB1 antibody is un-conjugated
(13), (13), (13), (8), (8), (8), (5), (5), (5), (5), (5), (5), (5), (5), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(219), (126), (87), (50), (38), (31), (16), (7), (5), (5), (2), (1), (1)
Pubmed 1 reference available
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Quantity 100 μg
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Immunogen Synthetic peptide directed towards the N terminal of human STK11
Sequence TLCRRAVKIL KKKKLRRIPN GEANVKKEIQ LLRRLRHKNV IQLVDVLYNE
Predicted Reactivity African clawed frog : 100 %, Chicken : 100 %, Dog : 100 %, Horse : 100 %, Human : 100 %, Mouse : 100 %, Rat : 100 %, Zebrafish : 100 %
Characteristics This is a rabbit polyclonal antibody against STK11. It was validated on Western Blot and immunohistochemistry.
Purification Protein A purified
Alternative Name STK11 (STK11 Antibody Abstract)
Background STK11is a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in its gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms.This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
Molecular Weight 48 kDa
Gene ID 6794
NCBI Accession NM_000455, NP_000446
UniProt Q15831
Pathways AMPK Signaling
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 433 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-LKB1 antibody (serine/threonine Kinase 11) (N-Term) (ABIN310216) WB Suggested Anti-STK11 Antibody Titration: 1.25ug/ml
Positive Control: ...
Immunohistochemistry (IHC) image for anti-LKB1 antibody (serine/threonine Kinase 11) (N-Term) (ABIN310216) anti-serine/threonine Kinase 11 (STK11) (N-Term) antibody (Image 2)
Background publications Xie, Dong, Zhang et al.: "Activation of protein kinase C zeta by peroxynitrite regulates LKB1-dependent AMP-activated protein kinase in cultured endothelial cells." in: The Journal of biological chemistry, Vol. 281, Issue 10, pp. 6366-75, 2006 (PubMed).

Catalog No. ABIN310216

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