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Details for Product No. ABIN310450

Ring Finger Protein 128 (RNF128) (C-Term) antibody

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Antigen
Synonyms GRAIL, 1300002C13Rik, AI987883, Greul1, RGD1566282, rnf128, wu:fb57h05, zgc:77843, grail, greul1
Epitope
»Alternatives C-Term
Reactivity
»Alternatives Mouse (Murine), Rat (Rattus), Dog (Canine), Cow (Bovine), Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN310450
Quantity 100 µg
Price
229.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen The immunogen for anti-RNF128 antibody: synthetic peptide directed towards the C terminal of human RNF128
Sequence LEEHVQSTNESLQLVNHEANSVAVDVIPHVDNPTFEEDET PNQETAVREI
Predicted Reactivity Human : 100%, Dog : 92%, Mouse : 92%, Rat : 92%
Characteristics This is a rabbit polyclonal antibody against RNF128. It was validated on Western Blot using a cell lysate as a positive control. We strive to provide antibodies covering each member of a whole protein family of your interest.
Purification Protein A purified
Alternative Name RNF128
Background RNF128 is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of RNF128 in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of RNF128 was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype.The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Molecular Weight 47kDa
Gene ID 79589
NCBI Accession NP_919445, NM_194463
UniProt Q8TEB7
Research Area Proteolysis / Ubiquitin
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100 µL of distilled water
Concentration 1mg/mL
Buffer Final anti-RNF128 antibody concentration is 1 mg/mL in PBS buffer.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Background publications Soares, Seroogy, Skrenta et al.: "Two isoforms of otubain 1 regulate T cell anergy via GRAIL." in: Nature immunology, Vol. 5, Issue 1, pp. 45-54, 2003 (PubMed).

Alternatives for antigen "Ring Finger Protein 128 (RNF128)", type "Antibodies"
Hosts (22)
Reactivities (13), (13), (13), (12), (12), (12), (9), (1), (1)
Applications (13), (10), (5), (3)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (3), (2), (2), (1), (1), (1)
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