Amine Oxidase, Copper Containing 2 (Retina-Specific) (AOC2) (Middle Region) antibody

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Antigen
Synonyms DAO2, RAO, Aoc2, Rao, aoc2, AOC2, AOC3
Epitope
Middle Region
(5), (4), (4), (2), (1), (1)
Reactivity
Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
(17), (5), (2), (2), (2), (2), (2), (2)
Host
Rabbit
(14), (3)
Clonality
Polyclonal
Application
Western Blotting (WB)
(17), (3), (1)
Pubmed 1 reference available
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Quantity 50 μg
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Immunogen Synthetic peptide directed towards the middle region of human AOC2
Blocking Peptide Blocking peptide for this product available: Amine Oxidase, Copper Containing 2 (Retina-Specific) (AOC2) peptide (ABIN973270)
Sequence QATMVDIHIL VGKGAVQLLP GAVCVFEEAQ GLPLRRHHNY LQNHFYGGLA
Predicted Reactivity Bovine : 100 %, Dog : 100 %, Human : 100 %, Mouse : 100 %, Rabbit : 100 %, Pig : 90 %
Characteristics This is a rabbit polyclonal antibody against AOC2. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name AOC2 (AOC2 Antibody Abstract)
Background Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes and ammonia in the presence of copper and quinone cofactor. The protein contains several conserved motifs including the active site of amine oxidases and the histidine residues that likely bind copper. It may be a critical modulator of signal transmission in retina, possibly by degrading the biogenic amines dopamine, histamine, and putrescine.Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes and ammonia in the presence of copper and quinone cofactor. This gene shows high sequence similarity to copper amine oxidases from various species ranging from bacteria to mammals. The protein contains several conserved motifs including the active site of amine oxidases and the histidine residues that likely bind copper. It may be a critical modulator of signal transmission in retina, possibly by degrading the biogenic amines dopamine, histamine, and putrescine. This gene may be a candidate gene for hereditary ocular diseases. Alternate splicing results in multiple transcript variants.
Molecular Weight 84 kDa
Gene ID 314
NCBI Accession NM_009590, NP_033720
UniProt O75106
Research Area Neurology
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 756 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-Amine Oxidase, Copper Containing 2 (Retina-Specific) (AOC2) (Middle Region) antibody (ABIN310657) WB Suggested Anti-AOC2 Antibody Titration: 0.2-1 ug/ml
Positive Control:...
Background publications Brandenberger, Wei, Zhang et al.: "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation." in: Nature biotechnology, Vol. 22, Issue 6, pp. 707-16, 2004 (PubMed).

Catalog No. ABIN310657
$289.00
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