Cytochrome C Oxidase Assembly Homolog 15 (Yeast) (COX15) (N-Term) antibody

Details for Product No. ABIN310821
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Antigen
Synonyms wu:fa18g06, zgc:56240, zgc:77422, CEMCOX2, 2900026G05Rik
Epitope
N-Term
(2), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Cow (Bovine), Dog (Canine), Zebrafish (Danio rerio), Human
(17), (8), (8)
Host
Rabbit
(14), (3)
Clonality
Polyclonal
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(12), (11), (7), (2)
Pubmed 1 reference available
Quantity 100 µg
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Catalog No. ABIN310821
229.00 $
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Immunogen Synthetic peptide directed towards the N terminal of human COX15
Sequence DWHLIKEMKP PTSQEEWEAE FQRYQQFPEF KILNHDMTLT EFKFIWYMEY
Predicted Reactivity Human : 100 %, Bovine : 90 %, Chicken : 90 %, Guinea pig : 90 %, Horse : 90 %, Mouse : 90 %, Rat : 90 %, Dog : 80 %, Rabbit : 80 %, Zebrafish : 70 %
Characteristics This is a rabbit polyclonal antibody against COX15. It was validated on Western Blot and immunohistochemistry.
Purification Protein A purified
Alternative Name COX15
Background Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be essential for the biogenesis of COX formation and may function in the hydroxylation of heme O, according to the yeast mutant studies. This protein is predicted to contain 5 transmembrane domains localized in the mitochondrial inner membrane.Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be essential for the biogenesis of COX formation and may function in the hydroxylation of heme O, according to the yeast mutant studies. This protein is predicted to contain 5 transmembrane domains localized in the mitochondrial inner membrane. Alternative splicing of this gene generates several transcript variants diverging in the 3' region including alternate poly A sites. In total, 2 different isoforms are encoded by these variants.
Molecular Weight 44 kDa
Gene ID 1355
NCBI Accession NP_004367, NM_004376
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 388 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Cytochrome C Oxidase Assembly Homolog 15 (Yeast) (COX15) (N-Term) antibody WB Suggested Anti-COX15 Antibody Titration: 5.0ug/ml
Positive Control: HepG2 cell lysate
Background publications Oquendo, Antonicka, Shoubridge et al.: "Functional and genetic studies demonstrate that mutation in the COX15 gene can cause Leigh syndrome." in: Journal of medical genetics, Vol. 41, Issue 7, pp. 540-4, 2004 (PubMed).

Validation Images
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