Chimerin (Chimaerin) 2 (CHN2) (N-Term) antibody

Details for Product No. ABIN311468
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Antigen
Synonyms 1700026N20Rik, 4930557O16Rik, ARHGAP3, Bch, BCH, CHN2-3, RHOGAP3
Epitope
N-Term
(8), (3), (2), (1), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Cow (Bovine), Xenopus laevis, Human, Chicken
(17), (6), (4), (2), (1), (1), (1), (1), (1)
Host
Rabbit
(17), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(18), (12), (1), (1)
Pubmed 1 reference available
Quantity 50 µg
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Catalog No. ABIN311468
289.00 $
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Immunogen Synthetic peptide directed towards the N terminal of human CHN2
Sequence AFGVKVGVKG GFLWPPLKLF ACSQISSLVR RAALTHNDNH FNYEKTHNFK
Predicted Reactivity Bovine : 100 %, Horse : 100 %, Human : 100 %, Mouse : 100 %, Rabbit : 100 %, Rat : 100 %, Chicken : 90 %, Guinea pig : 90 %, Pig : 90 %, African clawed frog : 70 %
Characteristics This is a rabbit polyclonal antibody against CHN2. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name CHN2
Background CHN2 is a protein with a phorbol-ester/DAG-type zinc finger, a Rho-GAP domain and an SH2 domain. This protein has GTPase-activating protein activity that is regulated by phospholipid binding and binding of diacylglycerol (DAG) induces translocation of the protein from the cytosol to the Golgi apparatus membrane. CHN2 plays a role in the proliferation and migration of smooth muscle cells. Decreased expression of this gene is associated with high-grade gliomas and breast tumors, and increased expression of this gene is associated with lymphomas. Mutations in this gene have been associated with schizophrenia in men.This gene is a member of the chimerin family and encodes a protein with a phorbol-ester/DAG-type zinc finger, a Rho-GAP domain and an SH2 domain. This protein has GTPase-activating protein activity that is regulated by phospholipid binding and binding of diacylglycerol (DAG) induces translocation of the protein from the cytosol to the Golgi apparatus membrane. The protein plays a role in the proliferation and migration of smooth muscle cells. Decreased expression of this gene is associated with high-grade gliomas and breast tumors, and increased expression of this gene is associated with lymphomas. Mutations in this gene have been associated with schizophrenia in men. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Molecular Weight 38 kDa
Gene ID 1124
NCBI Accession NM_001039936, NP_001035025
UniProt P52757
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 332 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Chimerin (Chimaerin) 2 (CHN2) (N-Term) antibody WB Suggested Anti-CHN2 Antibody Titration: 0.2-1 ug/ml
Positive Control: Human Liver
Background publications Uhl, Liu, Drgon et al.: "Molecular genetics of successful smoking cessation: convergent genome-wide association study results." in: Archives of general psychiatry, Vol. 65, Issue 6, pp. 683-93, 2008 (PubMed).

Validation Images
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