TSC22D1 antibody

Catalog No. ABIN317674

Product Details anti-TSC22D1 Antibody

Target: TSC22D1 (TSC22 Domain Family, Member 1 (TSC22D1))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TSC22D1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: This antibody detects endogenous levels of TSC-22 protein.

Purification: Affinity Chromatography using epitope-specific immunogen.

Application Details

Application Notes: ELISA: 1/20000-1/40000. Western Blot: 1/500-1/1000. Immunohistochemistry: 1/50-1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2 containing 0.05 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for TSC22D1

Target: TSC22D1 (TSC22 Domain Family, Member 1 (TSC22D1))

Alternative Name: TSC22D1 (TSC22D1 Products)

Synonyms: Ptg-2 antibody, TGFB1I4 antibody, TSC22 antibody, AA589566 antibody, AW105905 antibody, Egr5 antibody, TSC-22 antibody, Tgfb1i4 antibody, Tsc antibody, Tsc22 antibody, tsc22 antibody, TS22A antibody, fj34d05 antibody, wu:fj34d05 antibody, zgc:65869 antibody, zgc:85857 antibody, TSC22D1 antibody, tsc22d1 antibody, MGC69210 antibody, MGC186361 antibody, DKFZp459J163 antibody, TSC22 domain family member 1 antibody, TSC22 domain family, member 1 antibody, TSC22 domain family member 1 L homeolog antibody, TSC22D1 antibody, Tsc22d1 antibody, tsc22d1.L antibody, tsc22d1 antibody

Background: Transforming growth factor-beta-stimulated clone-22 (TSC-22) acts as a transcriptionalregulator to modulate cell growth and differentiation and cell death. TSC-22 contains a leucine zipper domain as well as a nuclear export signal, resulting in cytoplasmic localization in living cells. However, concomitant with the induction of apoptosis, TSC-22 translocates from the cytoplasm to the nucleus and shows transcriptional regulatory activity. TSC-22 acts as a major downstream component in the TGF-beta pathway, and also the PPARgamma signalling pathway. The association of these two pathways with tumor suppression, and the significant downregulation of TSC-22 mRNA in various cancer types, such as brain and salivary gland tumors, imply an antiproliferative role for TSC-22.Synonyms: Cerebral protein 2, KIAA1994, Regulatory protein TSC-22, TGFB-stimulated clone 22 homolog, TGFB1I4, TSC22, TSC22 domain family protein 1, Transforming growth factor beta-1-induced transcript 4 protein

Molecular Weight: approx. 16 kDa

Gene ID: 8848

NCBI Accession: NP_006013

UniProt: Q15714