GALR2 antibody

Catalog No. ABIN317752

Product Details anti-GALR2 Antibody

Target: GALR2 (Galanin Receptor 2 (GALR2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GALR2 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: This antibody detects endogenous levels of GALR2 protein.(region surrounding Ile238)

Purification: Affinity Chromatography using epitope-specific immunogen.

Application Details

Application Notes: ELISA: 1/40000approx. 1/60000. Western Blot: 1/500approx. 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS, pH ~7.2, 15 mM Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for GALR2

Target: GALR2 (Galanin Receptor 2 (GALR2))

Alternative Name: GALR2 (GALR2 Products)

Synonyms: GALNR2 antibody, mGalR antibody, GALR2 antibody, GAL2-R antibody, GALR-2 antibody, galanin receptor 2 antibody, transcription regulator. LacI family, raffinose related antibody, DNA-binding transcriptional regulator GalR antibody, galactose operon repressor antibody, galanin receptor type 2 antibody, GALR2 antibody, Galr2 antibody, LOC100037698 antibody, rafR antibody, galR2 antibody, LOC103690156 antibody

Background: Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30 amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7 transmembrane family of G protein coupled receptors. GALR2 interacts with the N terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi.Synonyms: GAL2-R, GALNR2, GALR-2, Galanin receptor type 2

Molecular Weight: approx. 40.0 kDa

Gene ID: 8811

NCBI Accession: NP_003848

UniProt: O43603

Pathways: cAMP Metabolic Process, Inositol Metabolic Process, Feeding Behaviour