RXFP2 antibody

Catalog No. ABIN317772

Product Details anti-RXFP2 Antibody

Target: RXFP2 (Relaxin/insulin-Like Family Peptide Receptor 2 (RXFP2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RXFP2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Specificity: This antibody detects endogenous levels of Relaxin Receptor 2 protein.

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse.

Purification: Affinity Chromatography using epitope-specific immunogen

Application Details

Application Notes: ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for RXFP2

Target: RXFP2 (Relaxin/insulin-Like Family Peptide Receptor 2 (RXFP2))

Alternative Name: Relaxin Receptor 2 / RXFP2 (RXFP2 Products)

Synonyms: GPR106 antibody, GREAT antibody, INSL3R antibody, LGR8 antibody, LGR8.1 antibody, RXFPR2 antibody, Gpcr antibody, Lgr8 antibody, Gpr106 antibody, Great antibody, lgr8.1 antibody, rxfp2 antibody, rxfp2b antibody, zgc:63668 antibody, relaxin/insulin like family peptide receptor 2 antibody, relaxin/insulin-like family peptide receptor 2 antibody, relaxin/insulin-like family peptide receptor 2a antibody, RXFP2 antibody, Rxfp2 antibody, rxfp2a antibody

Background: Relaxins are endocrine and autocrine/paracrine hormones belonging to the insulin gene superfamily. In several mammalian species, relaxin is best known for its role during pregnancy and parturition, when it is produced by the corpora lutea of ovaries and other reproductive tissues. The secretion of relaxin into the blood stream just before parturition results in a marked softening and lengthening of the pubic symphysis and a softening of the cervix, which facilitates the birth process. Also, by inhibiting uterine contractions, relaxin may influence the timing of parturition. Two previously characterized orphan receptors designated relaxin receptor 1 (LGR7) and 2 (LGR8) bind relaxin in several tissues, including reproductive tissues, brain, and heart. Upon ligand binding, the relaxin receptors activate adenylate cyclases through Gs proteins. Expression of the relaxin receptors in tissues other than reproductive ones suggests that they have additional physiological functions, such as regulating blood pressure and controlling vascular volume in the heart.Synonyms: G-protein coupled receptor 106, G-protein coupled receptor affecting testicular descent, GPR106, GREAT, LGR8, Leucine-rich repeat-containing G-protein coupled receptor 8, Relaxin family peptide receptor 2

Molecular Weight: approx. 86 kDa

Gene ID: 122042

NCBI Accession: NP_570718

UniProt: Q8WXD0

Pathways: cAMP Metabolic Process, Myometrial Relaxation and Contraction