GFRA4
Reactivity: Human
WB
Host: Rabbit
Polyclonal
unconjugated
Application Notes
ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
zgc:171814 antibody, AW060733 antibody, G630015H18Rik antibody, GDNF family receptor alpha 4 antibody, GDNF family receptor alpha 4a antibody, glial cell line derived neurotrophic factor family receptor alpha 4 antibody, GFRA4 antibody, gfra4a antibody, Gfra4 antibody
Background
Glial cell line-derived neurotrophic factor (GDNF) and the related neurotrophic factor neurturin (NTN) are potent survival factors for central and peripheral neurons. Receptors for these factors include GFRα-1 (previously designated GDNFR-α), GFRα-2 (also designated RETL2), GFRα-3 and GFRα-4 (also known as persephin receptor). The receptors do not contain transmembrane domains and are attached to the cell membrane by glycosylphosphoinositol linkage. Binding of GDNF or NTN to one of these receptors leads to the activation of the tyrosine kinase Ret. GFRα-4 mediates the activation and GDNF-induced autophosphorylation of the RET receptor. It is mainly expressed in the adult thyroid gland, but lower levels may also be detected in fetal adrenal and thyroid glands.Synonyms: GDNF family receptor alpha-4, GDNF receptor alpha-4, GFR-alpha-4, Persephin receptor