TNNI3 antibody

Catalog No. ABIN318833

Product Details anti-TNNI3 Antibody

Target: TNNI3 (Cardiac Troponin I (TNNI3))

Reactivity: Human

Host: Goat

Clonality: Polyclonal

Conjugate: This TNNI3 antibody is un-conjugated

Application: Enzyme Immunoassay (EIA)

Specificity: This antibody recognises human cardiac-specific troponin I, (TnI) an integral inhibitory protein of cardiac muscle which exists as a complex with troponin C (TnC) and troponin T (TnT).

Purification: Purified IgG prepared by Immunoaffinity chromatography

Immunogen: Native human cardiac troponin I, purity greater than 98%.

Isotype: IgG

Application Details

Application Notes: ELISA.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0mg/mL

Buffer: PBS buffer pH 7.4 containing 0.09 % Sodium Azide (NaN3)

Preservative: Sodium azide

Precaution of Use: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for TNNI3

Target: TNNI3 (Cardiac Troponin I (TNNI3))

Alternative Name: Cardiac Troponin I (TNNI3 Products)

Synonyms: CMD1FF antibody, CMD2A antibody, CMH7 antibody, RCM1 antibody, TNNC1 antibody, cTnI antibody, CMD1Z antibody, CMH13 antibody, TN-C antibody, TNC antibody, TNNC antibody, Tn1 antibody, TnIc antibody, ctnIc antibody, XTnIc antibody, c-troponin antibody, cTNT antibody, cmh7 antibody, ctni antibody, tnnc1 antibody, TNNI3 antibody, TnI antibody, cTNI antibody, AI874626 antibody, TnC antibody, cTnC antibody, tncc antibody, Tncc antibody, troponin I3, cardiac type antibody, troponin C1, slow skeletal and cardiac type antibody, troponin I, cardiac 3 antibody, troponin I type 3 (cardiac) antibody, troponin I3, cardiac type S homeolog antibody, troponin I3, cardiac type L homeolog antibody, cardiac troponin I antibody, troponin C, cardiac/slow skeletal antibody, TNNI3 antibody, TNNC1 antibody, Tnni3 antibody, tnni3.S antibody, tnni3.L antibody, tnni3 antibody, LOC100462680 antibody, Tnnc1 antibody

Background: The TnT subunit of troponin binds to tropomyosin to form a troponin-tropomyosin complex, anchored in place by the binding of TnI to actin, within muscle thin filaments. Structural change resulting from the binding of calcium to specific sites on the regulatory TnC subunit, releases the inhibitory region of TnI from actin, enabling the attachment of the molecular motor protein myosin, allowing for muscle contraction and hence movement. The measurement of blood TnI and TnT levels is an important diagnostic indicator of heart muscle damage, and can be used to differentiate between angina and myocardic infarction in patients with chest pain. Troponin I has also been shown to inhibit angiogenesis in vivo and in vitro.Synonyms: TNNC1, TNNI3

Gene ID: 7137

NCBI Accession: NP_000354

UniProt: P19429