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CTNNB1 antibody (Catenin (Cadherin-Associated Protein), beta 1, 88kDa) (Tyr654)

Details for Product anti-CTNNB1 Antibody No. ABIN319394, Supplier: Log in to see
Antigen
  • Jup
  • LOC100217813
  • CTNNB1
  • CTNNB
  • Bfc
  • Catnb
  • Mesc
  • ctnnb
  • id:ibd2058
  • wu:fb73e10
  • wu:fi81c06
  • wu:fk25h01
  • ctnnb1
  • CHBCAT
  • MRD19
  • armadillo
  • beta-catenin
  • catenin (cadherin-associated protein), beta 1, 88kDa
  • catenin (cadherin associated protein), beta 1
  • catenin (cadherin-associated protein), beta 1
  • CTNNB1
  • LOC100217813
  • Ctnnb1
  • ctnnb1
  • ctnnb1-a
  • ctnnb1-b
Alternatives
anti-Human CTNNB1 antibody for Enzyme Immunoassay
Epitope
Tyr654
82
20
19
19
18
16
14
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12
10
8
8
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5
5
5
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2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
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1
1
1
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1
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1
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1
1
1
1
1
1
1
1
1
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Reactivity
Human, Mouse (Murine), Rat (Rattus)
449
208
187
62
53
39
27
25
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24
15
13
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3
1
1
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Host
Rabbit
306
154
2
2
Clonality
Polyclonal
Conjugate
This CTNNB1 antibody is un-conjugated
15
12
9
6
6
6
4
4
Application
Western Blotting (WB)
418
154
110
107
102
69
66
30
16
13
8
7
4
3
3
2
1
1
1
Options
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Immunogen The antiserum was produced against synthesized non-phosphopeptide derived from human beta-Catenin around the phosphorylation site of Tyrosine 654 (A-T-YP-A-A).
Specificity This antibody detects endogenous levels of total beta-catenin protein.
Purification Immunoaffinity Chromatography.
Alternative Name Catenin beta-1 (CTNNB1 Antibody Abstract)
Background Synonyms: Beta-catenin, CTNNB, CTNNB1
Gene ID 1499
NCBI Accession NP_001091679
UniProt P35222
Research Area Signaling
Pathways WNT Signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Peptide Hormone Metabolism
Application Notes Western Blot (1/500-1/1000).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at-20 °C.
Supplier Images
 image for anti-CTNNB1 antibody (Catenin (Cadherin-Associated Protein), beta 1, 88kDa) (Tyr654) (ABIN319394) anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) (Tyr654) antibody
Background publications Provost, McCabe, Stern, Lizardi, DAquila, Rimm: "Functional correlates of mutation of the Asp32 and Gly34 residues of beta-catenin." in: Oncogene, Vol. 24, Issue 16, pp. 2667-76, 2005 (PubMed).

Provost, Yamamoto, Lizardi, Stern, DAquila, Gaynor, Rimm: "Functional correlates of mutations in beta-catenin exon 3 phosphorylation sites." in: The Journal of biological chemistry, Vol. 278, Issue 34, pp. 31781-9, 2003 (PubMed).

Amit, Hatzubai, Birman, Andersen, Ben-Shushan, Mann, Ben-Neriah, Alkalay: "Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway." in: Genes & development, Vol. 16, Issue 9, pp. 1066-76, 2002 (PubMed).

Liu, Li, Semenov, Han, Baeg, Tan, Zhang, Lin, He: "Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism." in: Cell, Vol. 108, Issue 6, pp. 837-47, 2002 (PubMed).