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Cathelicidin antibody (Cathelicidin Antimicrobial Peptide)

Details for Product anti-cAMP Antibody No. ABIN350184, Supplier: Log in to see
Antigen
  • CAP-18
  • CAP18
  • CATH-2
  • CATH-B1
  • CATHB1
  • CATHL2
  • CATHL7
  • Cnlp
  • Cramp
  • CRAMP
  • FALL-39
  • FALL39
  • LL37
  • MCLP
Reactivity
Human
73
30
20
6
1
1
Host
Rabbit
87
10
9
1
1
Clonality
Polyclonal
Conjugate
This Cathelicidin antibody is un-conjugated
7
3
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
59
36
32
20
16
5
5
4
3
2
Supplier
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Immunogen A synthetic peptide from human Cathelicidin antimicrobial peptide conjugated to an immunogenic carrier protein has been used as the antigen.
Isotype IgG
Specificity Specific for Cathelicidin antimicrobial peptide.
Alternative Name LL-37 (cAMP Antibody Abstract)
Background Cathelicidin antimicrobial protein is an antimicrobial protein found in specific granules of polymorphonuclear leukocytes.
Function: Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity.
Subcellular location: Secreted.
Tissue specificity: Expressed in bone marrow and testis and neutrophils. Also known as: CAMP, CAP18, FALL39, FALL-39, 18 kDa cationic antimicrobial protein, CAP-18, hCAP-18, LL37, CRAMP, HSD26.
Application Notes Use at a concentration of 10-50 µg/ml.
The optimal working concentration should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Supplier Images
 image for anti-Cathelicidin antibody (Cathelicidin Antimicrobial Peptide) (ABIN350184) Staining of a cytospin preparation of peripheral blood mononuclear cells isolated fro...
Western Blotting (WB) image for anti-Cathelicidin antibody (Cathelicidin Antimicrobial Peptide) (ABIN350184) WB on human neutrophil lysate using Rabbit antibody to human Cathelicidin antimicrobi...
Background publications Bals, Lang, Weiner, Vogelmeier, Welsch, Wilson: "Rhesus monkey (Macaca mulatta) mucosal antimicrobial peptides are close homologues of human molecules." in: Clinical and diagnostic laboratory immunology, Vol. 8, Issue 2, pp. 370-5, 2001 (PubMed).

Larrick, Lee, Ma, Li, Francke, Wright, Balint: "Structural, functional analysis and localization of the human CAP18 gene." in: FEBS letters, Vol. 398, Issue 1, pp. 74-80, 1997 (PubMed).

Gudmundsson, Agerberth, Odeberg, Bergman, Olsson, Salcedo: "The human gene FALL39 and processing of the cathelin precursor to the antibacterial peptide LL-37 in granulocytes." in: European journal of biochemistry / FEBS, Vol. 238, Issue 2, pp. 325-32, 1996 (PubMed).

Agerberth, Gunne, Odeberg, Kogner, Boman, Gudmundsson: "FALL-39, a putative human peptide antibiotic, is cysteine-free and expressed in bone marrow and testis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 1, pp. 195-9, 1995 (PubMed).

Cowland, Johnsen, Borregaard: "hCAP-18, a cathelin/pro-bactenecin-like protein of human neutrophil specific granules." in: FEBS letters, Vol. 368, Issue 1, pp. 173-6, 1995 (PubMed).

Larrick, Hirata, Balint, Lee, Zhong, Wright: "Human CAP18: a novel antimicrobial lipopolysaccharide-binding protein." in: Infection and immunity, Vol. 63, Issue 4, pp. 1291-7, 1995 (PubMed).