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Dynamin 1 antibody (DNM1)

Details for Product anti-DNM1 Antibody No. ABIN350299, Supplier: Log in to see
Antigen
  • dnm
  • DNM1
  • Dnm1
  • dnm1
  • si:dkey-246l19.2
  • DNM
  • AI838169
  • Dnm
  • Ftfl
  • mKIAA4093
Reactivity
Mouse (Murine), Rat (Rattus), Human
110
89
86
9
7
7
2
1
Host
Rabbit
95
10
8
Clonality
Polyclonal
Conjugate
This Dynamin 1 antibody is un-conjugated
3
3
3
3
3
3
3
3
3
3
3
3
Application
Immunohistochemistry (IHC), Western Blotting (WB)
75
33
32
30
14
4
3
2
2
1
1
1
Supplier
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Immunogen A synthetic peptide from rat Dynamin conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in human and mouse.
Isotype IgG
Specificity Specific for Dynamin 1.
Alternative Name Dynamin 1 (DNM1 Antibody Abstract)
Background Function: Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis.
Catalytic activity: GTP + H(2)O = GDP + phosphate.
Subcellular location: Cytoplasm. Cytoplasm › cytoskeleton. Also known as: Dynamin-1, D100, DNM, EC 3.6.5.5, B dynamin, DNM 1, DNM1, Dynamin, Dynamin BREDNM19, Dynamin1.
Research Area Neurology
Pathways
Application Notes A concentration of 10-50 µg/ml is recommended.
The optimal concentration should be determined by the end user. Not tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 150 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Graham, Anggono, Bache et al.: "The in vivo phosphorylation sites of rat brain dynamin I." in: The Journal of biological chemistry, Vol. 282, Issue 20, pp. 14695-707, 2007 (PubMed).

Reubold, Eschenburg, Becker et al.: "Crystal structure of the GTPase domain of rat dynamin 1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 37, pp. 13093-8, 2005 (PubMed).

Cousin, Robinson: "The dephosphins: dephosphorylation by calcineurin triggers synaptic vesicle endocytosis." in: Trends in neurosciences, Vol. 24, Issue 11, pp. 659-65, 2001 (PubMed).

Ringstad, Nemoto, De Camilli: "The SH3p4/Sh3p8/SH3p13 protein family: binding partners for synaptojanin and dynamin via a Grb2-like Src homology 3 domain." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 16, pp. 8569-74, 1997 (PubMed).

Obar, Collins, Hammarback et al.: "Molecular cloning of the microtubule-associated mechanochemical enzyme dynamin reveals homology with a new family of GTP-binding proteins." in: Nature, Vol. 347, Issue 6290, pp. 256-61, 1990 (PubMed).