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Pro Hepcidin (AA 39-59) antibody

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AA 39-59
Mouse (Murine)
Immunohistochemistry (IHC), Western Blotting (WB)
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Immunogen A synthetic peptide from aa region 39-59 of pro region of mouse Hepcidin conjugated to blue carrier protein has been used as the antigen.
Isotype IgG
Specificity Specific for Hepcidin.
Background Function: Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity.
Subcellular location: Secreted.
Tissue specificity: Highly expressed in the liver and to a much lesser extent in the heart. Also known as: Hepcidin, Liver-expressed antimicrobial peptide, LEAP-1, Putative liver tumor regressor, HAMP, HEPC, LEAP1.
Application Notes A concentration of 10-50 µg/ml is recommended.
The optimal concentration should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Nicolas, Bennoun, Devaux et al.: "Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 15, pp. 8780-5, 2001 (PubMed).

Pigeon, Ilyin, Courselaud et al.: "A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload." in: The Journal of biological chemistry, Vol. 276, Issue 11, pp. 7811-9, 2001 (PubMed).