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Stromal Interaction Molecule 1 (STIM1) (Extracellular Domain) antibody

Details for Product No. ABIN350881
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Antigen
Synonyms D11S4896E, GOK, TAM, SIM, stim1, MGC76045, STIM1, si:dkey-24p1.5, MGC154748, si:ch211-112l17.2, Stim1
Epitope
Extracellular Domain
(27), (8), (8), (6), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1)
Reactivity
Human, Rat (Rattus), Mouse (Murine)
(80), (48), (47), (25), (24), (18), (17), (2)
Host
Rabbit
(61), (23), (2), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(71), (35), (24), (23), (14), (11), (11), (8), (2), (2), (1), (1)
Pubmed 5 references available
Quantity 500 µg
Options
Shipping to United States (Change)
Availability Will be delivered in 7 to 8 Business Days
Catalog No. ABIN350881
454.67 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen A synthetic peptide from the extracellular domain of human Stromal interaction molecule 1 (STIM1) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in rat and mouse.
Specificity Specific for DRGX.
Purification IgG
Alternative Name Stromal interaction molecule 1 (STIM1, GOK)
Background Function: Plays a role in mediating Ca2+ influx following depletion of intracellular Ca2+ stores. Acts as Ca2+ sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca2+ depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca2+ release-activated Ca2+ (CRAC) channel subunit, TMEM142A/ORAI1.
Subcellular location: Cell membrane, Single-pass type I membrane protein. Endoplasmic reticulum membrane, Single-pass type I membrane protein. Note: Translocates from the endoplasmic reticulum to the cell membrane in response to a depletion of intracellular calcium.
Tissue specificity: Ubiquitously expressed in various human primary cells and tumor cell lines. Also known as: STIM1, GOK.
UniProt Q8BYH0
Research Area Chromatin and Nuclear Signaling, Transcription Factors, Neurogenesis
Application Notes A concentration of 10-50 µg/mL is recommended.
The optimal concentration should be determined by the end user.
Not tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability.
Expiry Date 12 months
General Parker, Begley, Smith et al.: "Molecular cloning of a novel human gene (D11S4896E) at chromosomal region 11p15.5." in: Genomics, Vol. 37, Issue 2, pp. 253-6, 1997 (PubMed).

Sabbioni, Barbanti-Brodano, Croce et al.: "GOK: a gene at 11p15 involved in rhabdomyosarcoma and rhabdoid tumor development." in: Cancer research, Vol. 57, Issue 20, pp. 4493-7, 1997 (PubMed).

Manji, Parker, Williams et al.: "STIM1: a novel phosphoprotein located at the cell surface." in: Biochimica et biophysica acta, Vol. 1481, Issue 1, pp. 147-55, 2000 (PubMed).

Williams, Manji, Parker et al.: "Identification and characterization of the STIM (stromal interaction molecule) gene family: coding for a novel class of transmembrane proteins." in: The Biochemical journal, Vol. 357, Issue Pt 3, pp. 673-85, 2001 (PubMed).

Chen, Jiang, Sun et al.: "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." in: Journal of proteome research, Vol. 8, Issue 2, pp. 651-61, 2009 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN350881
454.67 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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