SYT1 antibody (Synaptotagmin I)

Details for Product anti-SYT1 Antibody No. ABIN350918, Supplier: Log in to see
Antigen
  • CG3139
  • D. Syt I
  • DSYT
  • DSYT2
  • DSypt
  • DSyt
  • Dmel\\CG3139
  • Droso1
  • Dsyt2
  • SYT
  • SYT I
  • SYT1
  • Syt
  • Syt 1
  • Syt I
  • Syt-1
  • SytI
  • dSYT
  • dsyt1
  • dsytI
  • l(2)23AB1
  • l(2)23Ba
  • l(2)k05909
  • syt
  • syt 1
  • syt I
  • syt-1
  • syt1
  • sytI
  • Syti
  • GB20036
  • svp65
  • DKFZP459P193
  • 5430411C10Rik
  • GOLPH5
  • GRASP65
  • P65
  • SVP65
  • AW124717
  • G630098F17Rik
  • p65
  • Synaptotagmin 1
  • synaptotagmin I
  • synaptotagmin-1
  • synaptotagmin 1
  • DKFZP459P193 protein
  • golgi reassembly stacking protein 1
  • synaptotagmin VIII
  • synaptotagmin-like 1
  • synaptotagmin, p65
  • Syt1
  • Syti
  • SYT1
  • Tsp_06980
  • Tsp_08220
  • syt1
  • DKFZP459P193
  • Gorasp1
  • syt8
  • SYT8
  • SYTL1
  • LOC100533340
Alternatives
anti-Mouse (Murine) SYT1 antibody for Dot Blot
Reactivity
Mouse (Murine)
188
111
105
22
12
12
7
7
6
5
4
4
3
3
3
2
2
1
1
1
1
Host
Sheep
152
37
18
7
3
2
Clonality
Polyclonal
Conjugate
This SYT1 antibody is un-conjugated
10
9
9
4
4
4
2
2
2
2
2
2
2
2
2
Application
Immunohistochemistry (IHC), Western Blotting (WB)
180
78
77
43
25
22
13
11
4
3
3
2
2
1
Options
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Immunogen A synthetic peptide from human Synaptotagmin-1 (Synaptotagmin I) conjugated to an immunogenic carrier protein was used as the immunogen.
Isotype IgG
Specificity Specific for Synaptotagmin-1.
Alternative Name Synaptotagmin-1 (SYT1 Antibody Abstract)
Background Function: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner, these are neurexins, syntaxin and AP2.
Cofactor: Binds 3 calcium ions per subunit. The ions are bound to the C2 domains.
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Cytoplasmic vesicle, secretory vesicle, chromaffin granule. Note: Synaptic vesicles and chromaffin granules.
Tissue specificity: Predominantly expressed in rostral, phylogenetically younger brain regions, and in some endocrine tissues. Also known as: Synaptotagmin-1, Synaptotagmin I, SytI, p65, SVP65.
Pathways Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport
Application Notes A concentration of 10-50 µg/ml is recommended.
The optimal concentration should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Perin, Fried, Mignery, Jahn, Suedhof: "Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C." in: Nature, Vol. 345, Issue 6272, pp. 260-3, 1990 (PubMed).