TRPA1 antibody

Catalog No. ABIN351099

Product Details anti-TRPA1 Antibody

Target: TRPA1 (Transient Receptor Potential Cation Channel, Subfamily A, Member 1 (TRPA1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRPA1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificity: Specific for TRPA1.

Cross-Reactivity: Human

Cross-Reactivity (Details): Other species not yet tested.

Purification: IgG

Immunogen: A synthetic peptide from human TRPA1 conjugated to blue carrier protein was used as the antigen.

Isotype: IgG

Application Details

Application Notes: IHC, WB. Use at a concentration of 10-50 μg,ml. The optimal working concentration should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitute in 500 μL of sterile water. Centrifuge to remove any insoluble material.

Handling Advice: Avoid freeze and thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date: 12 months

Target Details for TRPA1

Target: TRPA1 (Transient Receptor Potential Cation Channel, Subfamily A, Member 1 (TRPA1))

Alternative Name: TRPA1 (TRPA1 Products)

Synonyms: trpa1 antibody, ANKTM1 antibody, Anktm1 antibody, CG5751 antibody, CG5761 antibody, CT18073 antibody, DmTRPA1 antibody, Dmel\\CG5751 antibody, TRPA antibody, TRPA1 antibody, TrpA antibody, dANKTM1 antibody, dTRPA antibody, dTRPA1 antibody, dTrpA antibody, dTrpA1 antibody, dtrpA1 antibody, trpA1 antibody, GLEAN_02449 antibody, FEPS antibody, transient receptor potential cation channel, subfamily A, member 1a antibody, Transient receptor potential cation channel A1 antibody, transient receptor potential cation channel subfamily A member 1 antibody, transient receptor potential A1 antibody, tryptophan synthase subunit alpha 1 antibody, transient receptor potential cation channel, subfamily A, member 1 antibody, TRPA cation channel homolog antibody, trpa1a antibody, TrpA1 antibody, TRPA1 antibody, LOC658860 antibody, LOC694623 antibody, trpA1 antibody, trpa1 antibody, Trpa1 antibody, trpa-1 antibody

Background: The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane proteins. The specific function of this protein has not yet been determined, however, studies indicate the function may involve a role in signal transduction and growth control. FUNCTION: Receptor-activated non-selective cation channel involved in detection of sensations such as cold, pain or sounds perception. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes. Also involved in pain sensation triggered by capsaicin, the pungent ingredient in chilli peppers. Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana. Not involved in menthol sensation. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system. SUBCELLULAR LOCATION: Membrane, Multi-pass membrane protein (Probable). TISSUE SPECIFICITY: Expressed at very low level. Expressed at very low level in human fibroblasts and at a moderate level in liposarcoma cells. MISCELLANEOUS: Inhibited by ruthenium red, a potent blocker of TRPV channels.,Mammalian TRPA,Transient receptor potential cation channel subfamily A member 1, ankyrin-like with transmembrane domains protein 1, transformation sensitive protein p120, ANKTM1

UniProt: O75762