Transient Receptor Potential Cation Channel, Subfamily A, Member 1 (TRPA1) (1st Cytoplasmic Loop) antibody

Antigen: Transient Receptor Potential Cation Channel, Subfamily A, Member 1 (TRPA1)

Synonyms: ANKTM1, CT18073, TRPA, TRPA1, dANKTM1, dTRPA1, Dmel\CG5751, CG5751, Anktm1, trpa1, GLEAN_02449

Binding Site: 1st Cytoplasmic Loop

Clonality: Polyclonal

Host: Rabbit

Reactivity: Caenorhabditis elegans (C. elegans)

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN351116

Additional Information

Alternative name: TRPA1 (ANKTM1,TRPa-1)

UniProt: Q18297

Immunogen: A synthetic peptide from the 1t cytoplasmic loop of C. Elegance TRPA1 (ANKTM1, trpa-1) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Isotype: IgG

Description: FUNCTION: Receptor-activated non-selective cation channel involved in the nose-touch response and foraging behavior. Contributes to the neural responses of sensory neurons to touch, particularly after repeated mechanical stimulation. Has no apparent role in thermosensory or chemosensory behaviors. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in many sensory neurons, including OLQ and IL1 neurons. MISCELLANEOUS: Worms lacking trpa-1 exhibit specific defects in mechanosensory behaviors: abnormal head withdrawal reflex, defective reversal behavior in response to nose-touch and foraging behaviors. Also known as: Transient receptor potential cation channel subfamily A member 1, ankyrin-like withtransmembrane domains protein 1, transformation sensitive protein p120, ANKTM1, trpa-1.

Specificity: Appears to be specific for TRPA1.

Application Details

Application Notes: IHC, WB. A concentration of 10-50 µg/ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.

Purity: IgG

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

"Genome sequence of the nematode C. elegans: a platform for investigating biology." in: Science (New York, N.Y.), Vol. 282, Issue 5396, pp. 2012-8, 1998 (PubMed).

Kindt, Viswanath, Macpherson et al.: "Caenorhabditis elegans TRPA-1 functions in mechanosensation." in: Nature neuroscience, Vol. 10, Issue 5, pp. 568-77, 2007 (PubMed).