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SEC22 Vesicle Trafficking Protein Homolog B (S. Cerevisiae) (Gene/pseudogene) (SEC22B) antibody
|Synonyms||ERS-24, SEC22L1, C81333, Sec22l1, AA517334, AI480645, 4930564D15Rik, sec22l1, MGC64555|
Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
|10 references available|
|Price||454.67 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 7 to 8 Business Days|
|Alternative name||Vesicle-trafficking protein SEC22b (SEC22B, SEC22L1, ERS24)|
|Immunogen||A synthetic peptide as a part of human, rat, mouse, hamster, orangutan, chicken Vesicle-trafficking protein SEC22b (SEC22B, SEC22L1, ERS24) conjugated to an immunogenic carrier protein was used as the immunogen.|
|Description||The protein encoded by this gene is a member of the SEC22 family of vesicle trafficking proteins. It seems to complex with SNARE and it is thought to play a role in the ER-Golgi protein trafficking. This protein has strong similarity to Mus musculus and Cricetulus griseus proteins. There is evidence for use of multiple polyadenylation sites for the transcript. FUNCTION: SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER. SUBUNIT: Component of two distinct SNARE complexes consisting of STX5,GOSR2/BOS1, BET1 and SEC22B or STX18, USE1L, BNIP1/SEC20L and SEC22B. YKT6 can probably replace SEC22B in either complex. SUBCELLULAR LOCATION: Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type IV membrane protein. Golgi apparatus membrane; Single-pass type IV membrane protein. Melanosome. Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Also known as: SEC22 vesicle-trafficking protein homolog B, SEC22 vesicle-trafficking protein-like 1, ERS24, ERS-24, Vesicle-trafficking protein SEC22b, SEC22L1, SEC22B.|
|Specificity||Appears to be specific for SEC22B.|
|Application Notes||IHC, WB. A working concentration of 10-50 µg/ml is recommended. The optimal concentration should be determined by the end user.|
|Storage||Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.|
|Restrictions||For Research Use only|
Hay, Chao, Kuo et al.: "Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells." in: Cell, Vol. 89, Issue 1, pp. 149-58, 1997 (PubMed).
Mao, Fu, Wu et al.: "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 14, pp. 8175-80, 1998 (PubMed).
Xu, Joglekar, Williams et al.: "Subunit structure of a mammalian ER/Golgi SNARE complex." in: The Journal of biological chemistry, Vol. 275, Issue 50, pp. 39631-9, 2001 (PubMed).
Gonzalez, Weis, Scheller: "A novel snare N-terminal domain revealed by the crystal structure of Sec22b." in: The Journal of biological chemistry, Vol. 276, Issue 26, pp. 24203-11, 2001 (PubMed).
Volchuk, Ravazzola, Perrelet et al.: "Countercurrent distribution of two distinct SNARE complexes mediating transport within the Golgi stack." in: Molecular biology of the cell, Vol. 15, Issue 4, pp. 1506-18, 2004 (PubMed).
Nakajima, Hirose, Taniguchi et al.: "Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion." in: The EMBO journal, Vol. 23, Issue 16, pp. 3216-26, 2004 (PubMed).
Carninci, Kasukawa, Katayama et al.: "The transcriptional landscape of the mammalian genome." in: Science (New York, N.Y.), Vol. 309, Issue 5740, pp. 1559-63, 2005 (PubMed).
Chi, Valencia, Hu et al.: "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes." in: Journal of proteome research, Vol. 5, Issue 11, pp. 3135-44, 2006 (PubMed).
Villén, Beausoleil, Gerber et al.: "Large-scale phosphorylation analysis of mouse liver." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 5, pp. 1488-93, 2007 (PubMed).
Matsuoka, Ballif, Smogorzewska et al.: "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." in: Science (New York, N.Y.), Vol. 316, Issue 5828, pp. 1160-6, 2007 (PubMed).
|Hosts||Rabbit (6), Sheep (3), Mouse (2)|
|Reactivities||Human (7), Mouse (Murine) (2), Rat (Rattus) (2)|
|Applications||Western Blotting (WB) (10), ELISA (5), Immunohistochemistry (IHC) (3), Immunohistochemistry (Fixed) (IHC (fx)) (2), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (2), Immunofluorescence (IF) (1)|