SLC17A8 antibody (Solute Carrier Family 17 (Sodium-Dependent Inorganic Phosphate Cotransporter), Member 8) (Internal Region)

Details for Product anti-SLC17A8 Antibody No. ABIN351387, Supplier: Log in to see
Antigen
  • vglut3
  • si:ch211-264e16.4
  • BC042593
  • Vglut3
  • DFNA25
  • VGLUT3
  • solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8
  • vesicular glutamate transporter 3
  • solute carrier family 17 (vesicular glutamate transporter), member 8
  • SLC17A8
  • slc17a8
  • Tsp_11966
  • Tsp_00373
  • Slc17a8
Alternatives
anti-Rat (Rattus) SLC17A8 antibody for ELISA
Epitope
Internal Region
37
27
3
1
1
Reactivity
Rat (Rattus)
46
42
25
2
Host
Rabbit
41
12
1
1
Clonality
Polyclonal
Conjugate
This SLC17A8 antibody is un-conjugated
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
52
50
19
19
4
3
2
2
2
1
1
Options
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Immunogen A synthetic peptide from the internal region of rat VGLUT3 conjugated to an immunogenic carrier protein was used as the antigen.
Isotype IgG
Specificity Specific for VGLUT3.
Alternative Name VGluT3 (SLC17A8 Antibody Abstract)
Background Function: Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.
Subcellular location: Cytoplasmic vesicle › secretory vesicle › synaptic vesicle membrane. Membrane, Multi-pass membrane proteinPotential. Cell junction › synapse › synaptosome.
Tissue specificity: Expressed in brain, kidney and liver. Expressed within the amygdala, brainstem, cerberal cortex, dorsal root ganglia, dorsal spinal cord, hippocampus, hypothalamus, retina, striatum and ventral spinal cord. Expressed within neurons of the caudate-putamen,olfactory tubercle, nucleus accumbens, hippocampus, interpeduncular nucleus and dorsal and medial raphe nuclei. Expressed in inner hair cells of the ear. Expressed at synaptic terminals within the lateral superior olive (LSO), a nucleus of the mammalian sound localization system, and in the medial nucleus of the trapezoid body (MNTB), which provides inhibitory input to the LSO. Also known as: Vesicular glutamate transporter 3, Solute carrier family 17 member 8.
Pathways Sensory Perception of Sound, Dicarboxylic Acid Transport
Application Notes A concentration of 10-50 µg/ml is recommended.
The optimal concentration should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Seal, Akil, Yi, Weber, Grant, Yoo, Clause, Kandler, Noebels, Glowatzki, Lustig, Edwards: "Sensorineural deafness and seizures in mice lacking vesicular glutamate transporter 3." in: Neuron, Vol. 57, Issue 2, pp. 263-75, 2008 (PubMed).

Takamori, Holt, Stenius, Lemke, Grønborg, Riedel, Urlaub, Schenck, Brügger, Ringler, Müller, Rammner, Gräter, Hub, De Groot, Mieskes, Moriyama, Klingauf, Grubmüller, Heuser, Wieland, Jahn: "Molecular anatomy of a trafficking organelle." in: Cell, Vol. 127, Issue 4, pp. 831-46, 2006 (PubMed).

Gras, Herzog, Bellenchi, Bernard, Ravassard, Pohl, Gasnier, Giros, El Mestikawy: "A third vesicular glutamate transporter expressed by cholinergic and serotoninergic neurons." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 22, Issue 13, pp. 5442-51, 2002 (PubMed).

Fremeau, Burman, Qureshi, Tran, Proctor, Johnson, Zhang, Sulzer, Copenhagen, Storm-Mathisen, Reimer, Chaudhry, Edwards: "The identification of vesicular glutamate transporter 3 suggests novel modes of signaling by glutamate." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 22, pp. 14488-93, 2002 (PubMed).

Schaefer, Varoqui, Defamie, Weihe, Erickson: "Molecular cloning and functional identification of mouse vesicular glutamate transporter 3 and its expression in subsets of novel excitatory neurons." in: The Journal of biological chemistry, Vol. 277, Issue 52, pp. 50734-48, 2002 (PubMed).

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