Protein Arginine Methyltransferase 2 (PRMT2) (C-Term) antibody

Details for Product No. ABIN356523
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Antigen
Synonyms PRMT2, DKFZp459N1919, HRMT1L1, Hrmt1l1, AI504737
Epitope
C-Term
(16), (9), (2), (2), (2), (2), (2), (2), (1), (1)
Reactivity
Human
(66), (5), (4), (2), (2), (1)
Host
Rabbit
(40), (26), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2)
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
(61), (22), (17), (14), (6), (2), (2), (2), (2), (1), (1)
Pubmed 3 references available
Quantity 0.4 mL
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Catalog No. ABIN356523
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human PRMT2.
Isotype Ig
Specificity This antibody is specific to PRMT2 (C-term).
Purification Protein G Chromatography eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name PRMT2
Background Arginine methylation is an irreversible post translational modification which has only recently been linked to protein activity. At least three types of PRMT enzymes have been identified in mammalian cells. These enzymes have been shown to have essential regulatory functions by methylation of key proteins in several fundamental areas. These protein include nuclear proteins, IL enhancer binding factor, nuclear factors, cell cycle proteins, signal transduction proteins, apoptosis proteins, and viral proteins. The mammalian PRMT family currently consists of 7 members that share two large domains of homology. Outside of these domains, epitopes were identified and antibodies against all 7 PRMT members have been developed.Synonyms: HMT1, HRMT1L1, Histone-arginine N-methyltransferase PRMT2, Protein arginine N-methyltransferase 2
Gene ID 3275, 9606
UniProt P55345
Research Area Chromatin and Nuclear Signaling
Application Notes ELISA: 1/1,000. Western blotting: 1/100-1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Supplier Images
anti-Protein Arginine Methyltransferase 2 (PRMT2) (C-Term) antibody anti-Protein Arginine Methyltransferase 2 (PRMT2) (C-Term) antibody
Background publications Katsanis, Yaspo, Fisher: "Identification and mapping of a novel human gene, HRMT1L1, homologous to the rat protein arginine N-methyltransferase 1 (PRMT1) gene." in: Mammalian genome : official journal of the International Mammalian Genome Society, Vol. 8, Issue 7, pp. 526-9, 1997 (PubMed).

Scott, Antonarakis, Lalioti et al.: "Identification and characterization of two putative human arginine methyltransferases (HRMT1L1 and HRMT1L2)." in: Genomics, Vol. 48, Issue 3, pp. 330-40, 1998 (PubMed).

Qi, Chang, Zhu et al.: "Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha." in: The Journal of biological chemistry, Vol. 277, Issue 32, pp. 28624-30, 2002 (PubMed).

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