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Euchromatic Histone-Lysine N-Methyltransferase 1 (EHMT1) (N-Term) antibody

Details for Product No. ABIN356541, Supplier: Login to see
Antigen
  • EHMT1
  • G9a
  • 9230102N17Rik
  • D330003E03
  • Eu-HMTase1
  • GLP
  • GLP1
  • KMT1D
  • mKIAA1876
  • EUHMTASE1
  • FP13812
  • bA188C12.1
Epitope
N-Term
35
28
20
20
4
4
3
3
2
2
1
1
1
1
1
1
1
1
1
Reactivity
Human
115
4
3
1
Host
Rabbit
97
17
1
Clonality
Polyclonal
Conjugate
Un-conjugated
10
10
10
10
10
5
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
100
73
10
5
4
3
3
3
Supplier
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human EHMT1.
Isotype Ig
Specificity This antibody is specific to EHMT1 (N-term).
Purification Protein A Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name EHMT1 (EHMT1 Antibody Abstract)
Background EHMT1, also known as EUHMTASE1, is a histone methyltransferase. This protein methylates 'Lys-9' of histone H3 in vitro. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. EHMT1 is Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in the G0/G1 transition of the cell cycle.Synonyms: EUHMTASE1, Eu-HMTase1, Euchromatic histone-lysine N-methyltransferase 1, G9a-like protein 1, GLP, GLP1, H3-K9-HMTase 5, Histone H3-K9 methyltransferase 5, Histone-lysine N-methyltransferase EHMT1, KIAA1876, KMT1D, Lysine N-methyltransferase 1D
Gene ID 79813, 9606
UniProt Q9H9B1
Pathways
Application Notes ELISA: 1/1,000. Western Blot: 1/50-1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Supplier Images
 image for anti-Euchromatic Histone-Lysine N-Methyltransferase 1 (EHMT1) (N-Term) antibody (ABIN356541) anti-Euchromatic Histone-Lysine N-Methyltransferase 1 (EHMT1) (N-Term) antibody
Background publications Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Ogawa, Ishiguro, Gaubatz et al.: "A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells." in: Science (New York, N.Y.), Vol. 296, Issue 5570, pp. 1132-6, 2002 (PubMed).