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GFAP antibody (Glial Fibrillary Acidic Protein) (N-Term)

Details for Product anti-GFAP Antibody No. ABIN357395, Supplier: Log in to see
Antigen
  • GFAP
  • AI836096
  • cb345
  • etID36982.3
  • gfapl
  • wu:fb34h11
  • wu:fk42c12
  • xx:af506734
  • zgc:110485
  • glial fibrillary acidic protein
  • GFAP
  • LOC100136168
  • gfap
  • Gfap
Epitope
N-Term
71
64
31
31
26
16
15
9
6
5
5
5
4
4
3
3
3
3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
735
402
389
193
189
138
101
38
33
32
25
24
22
21
12
7
7
3
3
3
3
2
2
1
1
1
1
1
1
1
Host
Rabbit
454
314
27
25
4
3
2
Clonality
Polyclonal
Conjugate
This GFAP antibody is un-conjugated
33
24
24
17
11
11
9
8
8
7
5
5
5
5
5
5
5
5
4
4
4
4
4
4
4
4
4
4
4
4
4
3
3
3
3
3
3
3
3
2
2
2
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
615
338
262
262
230
229
135
86
78
40
16
15
13
12
9
8
8
7
6
6
5
4
3
1
1
1
1
1
1
1
Options
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human GFAP.
Isotype Ig
Specificity This antibody detects GFAP N-term.
Purification Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Alternative Name GFAP (GFAP Antibody Abstract)
Background GFAP is one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system.Synonyms: Glial Fibrillary Acidic Protein
Molecular Weight 49880 Da
Gene ID 2670
NCBI Accession NP_001124491
UniProt P14136
Research Area Stem Cells, Cytoskeleton, Glia marker, Cell/Tissue Markers, Neurology
Application Notes ELISA 1: 1,000. Western blot 1: 100 - 1: 500. Immunohistochemistry 1: 50 - 1: 100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.
Supplier Images
 image for anti-GFAP antibody (Glial Fibrillary Acidic Protein) (N-Term) (ABIN357395) anti-Glial Fibrillary Acidic Protein (GFAP) (N-Term) antibody
 image for anti-GFAP antibody (Glial Fibrillary Acidic Protein) (N-Term) (ABIN357395) anti-Glial Fibrillary Acidic Protein (GFAP) (N-Term) antibody (Image 2)
Background publications Quintanar, Franco, Salinas: "Detection of glial fibrillary acidic protein and neurofilaments in the cerebrospinal fluid of patients with neurocysticercosis." in: Parasitology research, Vol. 90, Issue 4, pp. 261-3, 2003 (PubMed).

Shiroma, Kanazawa, Kato, Shimozawa, Imamura, Ito, Ohtani, Oka, Wakabayashi, Iai, Sugai, Sasaki, Kaga, Ohta, Tsujino: "Molecular genetic study in Japanese patients with Alexander disease: a novel mutation, R79L." in: Brain & development, Vol. 25, Issue 2, pp. 116-21, 2003 (PubMed).

Nielsen, Holm, Johansen, Bonven, Jørgensen, Jørgensen: "A new splice variant of glial fibrillary acidic protein, GFAP epsilon, interacts with the presenilin proteins." in: The Journal of biological chemistry, Vol. 277, Issue 33, pp. 29983-91, 2002 (PubMed).

Namekawa, Takiyama, Aoki, Takayashiki, Sakoe, Shimazaki, Taguchi, Tanaka, Nishizawa, Saito, Matsubara, Nakano: "Identification of GFAP gene mutation in hereditary adult-onset Alexander's disease." in: Annals of neurology, Vol. 52, Issue 6, pp. 779-85, 2002 (PubMed).

Lopez-Egido, Cunningham, Berg, Oberg, Bongcam-Rudloff, Gobl: "Menin's interaction with glial fibrillary acidic protein and vimentin suggests a role for the intermediate filament network in regulating menin activity." in: Experimental cell research, Vol. 278, Issue 2, pp. 175-83, 2002 (PubMed).