2'-5'-Oligoadenylate Synthetase 3, 100kDa (OAS3) (C-Term) antibody

Antigen: 2'-5'-Oligoadenylate Synthetase 3, 100kDa (OAS3)

Synonyms: p100, MGC133260, Oasl10, OAS3

Epitope: C-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Enzyme Immunoassay (EIA), Western Blotting (WB)

Catalog no.: ABIN358718

Additional Information

Characteristics: Synonyms: 2-5A synthetase 3, p100 OAS, 2'-5'-oligoadenylate synthetase 3, (2-5')oligo(A) synthetase 3

Alternative name: OAS3

Gene ID: 4940

Swiss-Prot: Q9Y6K5

Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated syntheticpeptide selected from the C-terminal region of human OAS3.

Cross-Reactivity: Human

Isotype: Ig  (Matching secondary antibodies)

Description: OAS3 is an interferon inducible protein that belongs to the 2-5A synthetase family, mayplay a role in mediating resistance to virus infection, control of cell growth, differentiation,and apoptosis. OAS3 synthesizes preferentially dimeric 2',5'-oligoadenylate molecules. GTP can be an alternative substrate. OAS3 binds double-stranded RNA and polymerizesATP into PPP(A2'P5'A)N oligomers, which activate the latent RNase L that, when activated,cleaves single-stranded RNAs. The protein is present at high level in placenta trophoblast.

Specificity: This antibody reacts to OAS3. Species: Human. Others not tested.

Application Details

Application Notes: ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: PBS with 0.09% (W/V) sodium azide

Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. Caution: This product is for research use only. Not for use in diagnostic or therapeutic procedures.

Restrictions: For Research Use only