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Details for Product No. ABIN358990

Parkinson Protein 2, E3 Ubiquitin Protein Ligase (PARK2) (N-Term) antibody

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Antigen
Synonyms Park, Prkn
Epitope
»Alternatives N-Term
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN358990
Quantity 0.4 mL
Price
346.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide in the N-terminal region of human Park2.
Specificity This antibody reacts to PARK2 (Parkin).
Purification Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
Alternative Name PARK2 / Parkin
Background Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson disease identified to date. The function of Park2 is not well-known, however, it may play a role in the ubiquitin-mediated proteolytic pathway. Mutations in this gene are known to cause autosomal recessive juvenile parkinsonism. Alternative splicing of this gene produces three known products of undetermined function.
Alternate names: AR-JP, E3 ubiquitin-protein ligase parkin, LPRS2, PDJ, PRKN, Parkinson disease 2, Parkinson juvenile disease protein 2
Gene ID 5071
NCBI Accession NP_004553.2
UniProt O60260
Application Notes ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immunohistochemistry: 1/50 - 1/100. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09% (w/v) sodium azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.
Expiry Date 12 months
Background publications West, Kapatos, OFarrell et al.: "N-myc regulates parkin expression." in: The Journal of biological chemistry, Vol. 279, Issue 28, pp. 28896-902, 2004 (PubMed).

Wang, Denison, Lai et al.: "Parkin gene alterations in hepatocellular carcinoma." in: Genes, chromosomes & cancer, Vol. 40, Issue 2, pp. 85-96, 2004 (PubMed).

Yao, Gu, Nakamura et al.: "Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 29, pp. 10810-4, 2004 (PubMed).

Pigullo, De Luca, Barone et al.: "Mutational analysis of parkin gene by denaturing high-performance liquid chromatography (DHPLC) in essential tremor." in: Parkinsonism & related disorders, Vol. 10, Issue 6, pp. 357-62, 2004 (PubMed).

Kumru, Santamaria, Tolosa et al.: "Rapid eye movement sleep behavior disorder in parkinsonism with parkin mutations." in: Annals of neurology, Vol. 56, Issue 4, pp. 599-603, 2004 (PubMed).

Alternatives for antigen "Parkinson Protein 2, E3 Ubiquitin Protein Ligase (PARK2)", type "Antibodies"
Hosts (72), (12), (8)
Reactivities (81), (17), (14), (5), (3), (2), (2)
Applications (74), (40), (24), (18), (10), (8), (6), (5), (4), (2), (1), (1), (1)
Conjugates (1)
Epitopes (10), (10), (8), (5), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
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