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BBS4 antibody (Bardet-Biedl Syndrome 4) (Middle Region)

Details for Product anti-BBS4 Antibody No. ABIN359722, Supplier: Log in to see
Antigen
  • AW537059
  • AW742241
  • CG13232
  • D9Ertd464e
  • Dmel\\CG13232
  • zgc:152964
Alternatives
anti-Human BBS4 antibody for Immunohistochemistry
Epitope
Middle Region
12
7
6
5
4
4
3
2
2
2
1
Reactivity
Human
77
26
24
6
6
4
2
2
2
2
Host
Rabbit
38
28
11
Clonality
Polyclonal
Conjugate
This BBS4 antibody is un-conjugated
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
65
27
12
4
4
3
2
2
2
Supplier
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the Center region of human BBS4.
Isotype Ig
Specificity This antibody reacts to BBS4.
Purification Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
Alternative Name BBS4 (BBS4 Antibody Abstract)
Background BBS4 contains tetratricopeptide repeats (TPR), similar to O-linked N-acetyglucosamine transferase. Mutations in the gene encoding this protein have been observed in patients with Bardet-Biedl syndrome type 4. BBS4 may play a role in pigmentary retinopathy, obesity, polydactyly, renal malformation and mental retardation.Synonyms: Bardet-Biedl syndrome 4 protein
Gene ID 585, 9606
UniProt Q96RK4
Research Area Neurology
Pathways Hedgehog Signaling
Application Notes ELISA: 1/1,000. Western blotting: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-BBS4 antibody (Bardet-Biedl Syndrome 4) (Middle Region) (ABIN359722) Western blot analysis of anti-BBS4 Pab in Hela cell line lysates (35ug/lane).BBS4 (ar...
Background publications Nachury, Loktev, Zhang, Westlake, Peränen, Merdes, Slusarski, Scheller, Bazan, Sheffield, Jackson: "A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis." in: Cell, Vol. 129, Issue 6, pp. 1201-13, 2007 (PubMed).

Ye, Dai, Fang, Jin, Guo, Song, Ji, Gu, Xie, Mao: "Cloning and characterization of a splice variant of human Bardet-Biedl syndrome 4 gene (BBS4)." in: DNA sequence : the journal of DNA sequencing and mapping, Vol. 15, Issue 3, pp. 213-8, 2004 (PubMed).

Kim, Badano, Sibold, Esmail, Hill, Hoskins, Leitch, Venner, Ansley, Ross, Leroux, Katsanis, Beales: "The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression." in: Nature genetics, Vol. 36, Issue 5, pp. 462-70, 2004 (PubMed).