BBS4 antibody (N-Term)

Catalog No. ABIN2787344

This Rabbit Polyclonal antibody specifically detects BBS4 in WB. It exhibits reactivity toward Human, Mouse, Rat, Dog, Horse, Cow, Rabbit, Zebrafish (Danio rerio), Guinea Pig and Pig.

Quick Overview for BBS4 antibody (N-Term) (ABIN2787344)

Target: BBS4 (Bardet-Biedl Syndrome 4 (BBS4))

Reactivity: Human, Mouse, Rat, Dog, Horse, Cow, Rabbit, Zebrafish (Danio rerio), Guinea Pig, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BBS4 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-BBS4 Antibody

Binding Specificity: N-Term

Purpose: BBS4 Antibody - N-terminal region

Sequence: YVQALIFRLE GNIQESLELF QTCAVLSPQS ADNLKQVARS LFLLGKHKAA

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against BBS4. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human BBS4

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP57695-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for BBS4

Target: BBS4 (Bardet-Biedl Syndrome 4 (BBS4))

Alternative Name: BBS4

Background:

Background Information: This gene is a member of the Bardet-Biedl syndrome (BBS) gene family. Bardet-Biedl syndrome is an autosomal recessive disorder characterized by severe pigmentary retinopathy, obesity, polydactyly, renal malformation and mental retardation. The proteins encoded by BBS gene family members are structurally diverse. The similar phenotypes exhibited by mutations in BBS gene family members are likely due to the protein's shared roles in cilia formation and function. Many BBS proteins localize to the basal bodies, ciliary axonemes, and pericentriolar regions of cells. BBS proteins may also be involved in intracellular trafficking via microtubule-related transport. The protein encoded by this gene has sequence similarity to O-linked N-acetylglucosamine (O-GlcNAc) transferases in plants and archaebacteria and in human forms a multi-protein "BBSome" complex with six other BBS proteins. Alternative splice variants have been described but their predicted protein products have not been experimentally verified.

Gene Name: Bardet-Biedl syndrome 4

Alternative Symbols: -

Protein Name: Bardet-Biedl syndrome 4 protein

Molecular Weight: 58kDa

Gene ID: 585

NCBI Accession: NP_149017

UniProt: Q96RK4

Pathways: Hedgehog Signaling, Tube Formation, Maintenance of Protein Location