Interleukin-1 Receptor-Associated Kinase 2 (IRAK2) (C-Term) antibody

Details for Product No. ABIN360118
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Antigen
Synonyms IRAK-2, 6330415L08Rik, AI649099, irak-2
Epitope
C-Term
(31), (11), (7), (5), (3), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(96), (35), (15)
Host
Rabbit
(95), (14)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(100), (60), (26), (25), (16), (10), (4), (3)
Pubmed 1 reference available
Catalog no. ABIN360118
Quantity 0.4 mL
Price
357.50 $   Plus shipping costs $45.00
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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human IRAK2.
Specificity This antibody reacts to IRAK2.
Purification Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Alternative Name IRAK2
Background Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains.The tyrosine-like kinase (TLK) group consists of 40 tyrosine and serine-threonine kinases such as MLK (mixed-lineage kinase), LISK (LIMK/TESK), IRAK (interleukin-1 receptor-associated kinase), Raf, RIPK (receptor-interacting protein kinase), and STRK (activin and TGF-beta receptors) families.
Alternate names: IRAK-2, Interleukin-1 receptor-associated kinase-like 2
Gene ID 3656
NCBI Accession 9606
UniProt O43187
Research Area Immunology, Innate Immunity, Cytokines, Receptors, Inflammation
Application Notes ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immunohistochemistry: 1/50 - 1/100. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09% (w/v) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.
Expiry Date 12 months
Supplier Images
anti-Interleukin-1 Receptor-Associated Kinase 2 (IRAK2) (C-Term) antibody anti-Interleukin-1 Receptor-Associated Kinase 2 (IRAK2) (C-Term) antibody
anti-Interleukin-1 Receptor-Associated Kinase 2 (IRAK2) (C-Term) antibody (2) anti-Interleukin-1 Receptor-Associated Kinase 2 (IRAK2) (C-Term) antibody (Image 2)
Background publications Muzio, Ni, Feng et al.: "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling." in: Science (New York, N.Y.), Vol. 278, Issue 5343, pp. 1612-5, 1997 (PubMed).

Hosts (95), (14)
Reactivities (96), (35), (15)
Applications (100), (60), (26), (25), (16), (10), (4), (3)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (31), (11), (7), (5), (3), (2), (1), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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