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PIK3C2B antibody (Phosphatidylinositol-4-Phosphate 3-Kinase, Catalytic Subunit Type 2 beta) (N-Term)

Details for Product anti-PIK3C2B Antibody No. ABIN360437, Supplier: Log in to see
Antigen
  • C2-PI3K
Epitope
N-Term
19
5
5
5
2
2
1
1
Reactivity
Human
34
5
Host
Rabbit
27
12
Clonality
Polyclonal
Conjugate
This PIK3C2B antibody is un-conjugated
3
3
2
2
2
2
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
32
24
17
6
5
1
1
1
Supplier
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human PI3KC2B.
Isotype Ig
Specificity This antibody reacts to PI3KC2B.
Purification Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Alternative Name PIK3C2B (PIK3C2B Antibody Abstract)
Background Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains.Synonyms: C2-PI3K, PI3K C2 beta, PI3K-C2-beta, Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit beta, Phosphoinositide 3-kinase-C2-beta, PtdIns-3-kinase C2 subunit beta
Gene ID 5287, 9606
UniProt O00750
Research Area Immunology, Innate Immunity, Metabolism
Application Notes ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immunohistochemistry: 1/10 - 1/50. Flow cytometry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Supplier Images
 image for anti-PIK3C2B antibody (Phosphatidylinositol-4-Phosphate 3-Kinase, Catalytic Subunit Type 2 beta) (N-Term) (ABIN360437) anti-Phosphatidylinositol-4-Phosphate 3-Kinase, Catalytic Subunit Type 2 beta (PIK3C2B) (N-Term) antibody
 image for anti-PIK3C2B antibody (Phosphatidylinositol-4-Phosphate 3-Kinase, Catalytic Subunit Type 2 beta) (N-Term) (ABIN360437) anti-Phosphatidylinositol-4-Phosphate 3-Kinase, Catalytic Subunit Type 2 beta (PIK3C2B) (N-Term) antibody (Image 2)
Background publications Arcaro, Volinia, Zvelebil et al.: "Human phosphoinositide 3-kinase C2beta, the role of calcium and the C2 domain in enzyme activity." in: The Journal of biological chemistry, Vol. 273, Issue 49, pp. 33082-90, 1999 (PubMed).

Brown, Ho, Weber-Hall et al.: "Identification and cDNA cloning of a novel mammalian C2 domain-containing phosphoinositide 3-kinase, HsC2-PI3K." in: Biochemical and biophysical research communications, Vol. 233, Issue 2, pp. 537-44, 1997 (PubMed).