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Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8) (C-Term) antibody

Details for Product No. ABIN360715
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Antigen
Synonyms TRPM8, trpp8, ltrpc6, trpm8b, LTRPC6, TRPP8, CMR1, LTrpC-6, Trp-p8
Epitope
C-Term
(10), (5), (5), (5), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(68), (29), (27), (13), (3), (2), (1), (1)
Host
Rabbit
(81), (3), (2), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(62), (27), (24), (23), (10), (9), (4), (2), (2), (1), (1)
Pubmed 3 references available
Quantity 0.4 mL
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Catalog No. ABIN360715
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide at the C-term of human TRPM8.
Specificity This antibody reacts to TRPM8.
Purification Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
Alternative Name TRPM8
Background TRPM8 is a receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. It is activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH and involved in menthol sensation. It is permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium.
Alternate names: LTRPC6, Long transient receptor potential channel 6, TRPP8, Transient receptor potential cation channel subfamily M member 8, Transient receptor potential-p8, Trp-p8
Gene ID 79054
NCBI Accession 9606
UniProt Q7Z2W7
Research Area Neurology, Metabolism
Application Notes ELISA: 1/1,000. Western blotting: 1/50 - 1/100. Immunohistochemistry: 1: /10 - 1/50. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09% (w/v) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.
Expiry Date 12 months
Supplier Images
anti-Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8) (C-Term) antibody anti-Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8) (C-Term) antibody
anti-Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8) (C-Term) antibody (2) anti-Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8) (C-Term) antibody (Image 2)
Background publications Tsavaler, Shapero, Morkowski et al.: "Trp-p8, a novel prostate-specific gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins." in: Cancer research, Vol. 61, Issue 9, pp. 3760-9, 2001 (PubMed).

Kiessling, Füssel, Schmitz et al.: "Identification of an HLA-A*0201-restricted T-cell epitope derived from the prostate cancer-associated protein trp-p8." in: The Prostate, Vol. 56, Issue 4, pp. 270-9, 2003 (PubMed).

Bödding, Wissenbach, Flockerzi: "Characterisation of TRPM8 as a pharmacophore receptor." in: Cell calcium, Vol. 42, Issue 6, pp. 618-28, 2007 (PubMed).

Validation Images
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