TRPM8 antibody (AA 1-192)

Catalog No. ABIN7172870

This Rabbit Polyclonal antibody specifically detects TRPM8 in ELISA, IHC and IF. It exhibits reactivity toward Human.

Quick Overview for TRPM8 antibody (AA 1-192) (ABIN7172870)

Target: TRPM8 (Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRPM8 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-TRPM8 Antibody

Binding Specificity: AA 1-192

Purpose: TRPM8 Antibody

Purification: Protein G purified

Purity: >95 %

Immunogen: Recombinant Human Transient receptor potential cation channel subfamily M member 8 protein (1-192AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TRPM8

Target: TRPM8 (Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8))

Alternative Name: TRPM8

Background:

Background: Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH . Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outward rectification and poor cationic selectivity. Isoform 2 and isoform 3 negatively regulate menthol- and cold-induced channel activity by stabilizing the closed state of the channel.

Aliases: Long transient receptor potential channel 6 antibody, LTrpC-6 antibody, LTrpC6 antibody, MGC2849 antibody, Short form of the TRPM8 cationic channel antibody, Transient receptor potential cation channel subfamily M member 8 antibody, Transient receptor potential p8 antibody, transient receptor potential-p8 antibody, Trp p8 antibody, Trp-p8 antibody, Trpm8 antibody, TRPM8_HUMAN antibody, TRPP8 antibody

UniProt: Q7Z2W7