KCNB2
Reactivity: Rat, Mouse
WB, IF (cc), IF (p)
Host: Rabbit
Polyclonal
AbBy Fluor® 594
Application Notes
Recommended Dilution: WB: 1:1000 IHC (frozen sections, unpublished observations): 1:1000 Quality Control: Western blots performed on each lot.
Restrictions
For Research Use only
Format
Liquid
Buffer
100 μL in 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.
Storage
-20 °C
Gravagna, Knoeckel, Taylor, Hultgren, Ribera: "Localization of Kv2.2 protein in Xenopus laevis embryos and tadpoles." in: The Journal of comparative neurology, Vol. 510, Issue 5, pp. 508-24, (2008) (PubMed).
Target
Kv2.2 (KCNB2)
(Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 2 (KCNB2))
KCNB2 antibody, si:ch211-193n21.1 antibody, Kv2.2 antibody, 9630047L19Rik antibody, BB130875 antibody, XShab12 antibody, kcnb2 antibody, KV2.2 antibody, potassium voltage-gated channel subfamily B member 2 antibody, potassium voltage-gated channel, Shab-related subfamily, member 2 antibody, potassium channel, voltage gated Shab related subfamily B, member 2 antibody, potassium voltage gated channel, Shab-related subfamily, member 2 antibody, potassium channel, voltage gated Shab related subfamily B, member 2 S homeolog antibody, KCNB2 antibody, kcnb2 antibody, LOC100051372 antibody, Kcnb2 antibody, kcnb2.S antibody
Background
Voltage-gated K+ channels are important determinants of neuronal membrane excitability (Pongs, 1999). Moreover, differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types. The delayed rectifier-type (IK)channels (Kv1.5, Kv2.1, and Kv2.2) are expressed on all neuronal somata and proximal dendrites and are also found in a wide variety of non-neuronal cells types including pancreatic islets, alveolar cells and cardiac myocytes (Hwang et al., 1993, Yan et al., 2004, Michaelevski et al., 2003). Kv2.1 and Kv2.2 form distinct populations of K+ channels and these subunits are thought to be primarily responsible for IK in superior cervical ganglion cells (Blaine and Ribera, 1998, Burger and Ribera, 1996). Anti-Voltage Gated Potassium Channel, Kv2.2-Subunit Western blot of rat brain homogenate showing specific immunolabeling of the ~125k voltage-gated potassium channel, Kv2.2 (Control). The immunolabeling is blocked by preadsorption with the peptide used as antigen (Peptide Block).