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Polo-Like Kinase Kinase (PLKK) (pSer482 486 490) antibody
| Antigen | Polo-Like Kinase Kinase (PLKK) |
| Epitope |
pSer482 486 490 |
| Clonality | Polyclonal |
| Host |
Rabbit |
| Reactivity |
Xenopus laevis |
| Application |
Western Blotting (WB)
|
| Catalog no. | ABIN361516 |
| Quantity | 100 µl |
| Price | 345.00 $ Plus shipping costs $35.00 |
| Shipping to |
|
| Availability | Ships within 5 to 7 Business Days |
Additional Information
| Alternative name | Phospho-Ser482,486,490 Polo-Like Kinase Kinase |
| Format | Affinity-purified |
| Description | Considerable evidence indicates that a polo-like kinase (PLK) plays an important role in cell cycle regulation. PLK is also required for bipolar spindle formation, activation of the anaphase-promoting complex/cyclosome, and cytokinesis. Recent work led to the identification of a PLKK that is thought to be responsible for activation of PLK. Recent work (Erikson, et al., 2004) has shown that PLKK is in turn activated by phosphorylation at three sites (Ser482, Ser486 and Ser490). Thus activation of PLK is thought to involve a kinase cascade involving the phosphorylation of Ser482,486,490 in PLKK. |
| Specificity | Specific for the ~120k PLKK protein phosphorylated at Ser482,486,490. |
Application Details
| Application Notes | Recommended Dilution: WB: 1:1000 Quality Control: Western blots performed on each lot. |
| Purification | Prepared from rabbit serum by affinity purification via sequential chromatography on phospho- and dephosphopeptide affinity columns. |
| Storage | Store at -20 °C, stable for 1 year |
| Restrictions | For Research Use only |
