Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) and Short Cytoplasmic Domain, (Semaphorin) 4D (SEMA4D) antibody

Details for Product No. ABIN361535
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Antigen
Synonyms C9orf164, CD100, M-sema-G, SEMAJ, coll-4, Semacl2, Semaj, Semcl2, COLL-4
Reactivity
Mouse (Murine), Human
(87), (26), (12), (12), (12), (12), (9)
Host
Mouse
(55), (39), (5), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(13), (6), (4), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Immunoprecipitation (IP), Flow Cytometry (FACS)
(54), (38), (25), (25), (10), (5), (4), (2), (1)
Pubmed 3 references available
Quantity 25 µg
Shipping to United States (Change)
Availability Will be delivered in 9 to 11 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN361535
948.34 $
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Immunogen Recombinant protein of Mouse Semaphorin 4D (extracellular domain)
Clone SK-3
Isotype IgG1 kappa
Purification ProteinG Affinity Purified
Alternative Name Semaphorin 4D
Background Semaphorins are a family of phylogeneticallyconserved soluble and transmembrane proteins. Semaphorins were originally identified as axon guidance factors during neuronal development.Semaphorins are now known to be widely expressed mediators that play significantroles in immune responses and organ morphogenesis. Sema4D (also known as CD100) is a 150-kDa transmembrane protein of the class IV semaphorin subfamily. Sema4D is expressed at high levels in lymphoid organs, including the spleen, thymus, and lymph nodes, and in non-lymphoidorgans, such as the brain, heart, andkidney. In lymphoid organs, Sema4D is expressed abundantly by T cells but weakly by B cells. Its expression is significantly enhanced inboth T and B cells, following their respective activation. Sema4D is proteolyticallycleaved from their transmembrane form to generate 120-kDa soluble forms. Two types of receptors, Plexin-B1 and CD72, have been identified for soluble Sema4D.
Gene ID 20354
Research Area Neurology
Application Notes ELISA: 1-10ug/ml. IP: 5ug/ml. FACS: 0.05ug/ml
Restrictions For Research Use only
Concentration 0.25 mg/ml
Buffer PBS [containing 2% Block Ace as a stabilizer, 0.1% Proclin as a bacteriostat]
Preservative ProClin
Storage -20 °C
General Kumanogoh, Watanabe, Lee et al.: "Identification of CD72 as a lymphocyte receptor for the class IV semaphorin CD100: a novel mechanism for regulating B cell signaling." in: Immunity, Vol. 13, Issue 5, pp. 621-31, 2001 (PubMed).

Kumanogoh, Suzuki, Chng et al.: "Requirement for the lymphocyte semaphorin, CD100, in the induction of antigen-specific T cells and the maturation of dendritic cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 3, pp. 1175-81, 2002 (PubMed).

Kumanogoh, Shikina, Watanabe et al.: "Requirement for CD100-CD72 interactions in fine-tuning of B-cell antigen receptor signaling and homeostatic maintenance of the B-cell compartment." in: International immunology, Vol. 17, Issue 10, pp. 1277-82, 2005 (PubMed).

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