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Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) and Short Cytoplasmic Domain, (Semaphorin) 4D (SEMA4D) antibody

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Synonyms C9orf164, CD100, M-sema-G, SEMAJ, coll-4, Semacl2, Semaj, Semcl2, COLL-4
Mouse (Murine), Human
(123), (35), (11), (9), (7), (5), (2), (2)
(92), (44), (17), (2)
Clonality (Clone)
Monoclonal ()
(19), (17), (11), (4), (1), (1)
Flow Cytometry (FACS), ELISA, Immunoprecipitation (IP)
(95), (57), (36), (27), (12), (7), (6), (5), (4), (3), (3), (3), (2), (2), (2), (2), (2)
Pubmed 3 references available
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Quantity 25 μg
Shipping to United States ( )
Availability Will be delivered in 9 to 11 Business Days
Immunogen Recombinant protein of Mouse Semaphorin 4D (extracellular domain)
Clone SK-3
Isotype IgG1 kappa
Purification ProteinG Affinity Purified
Alternative Name Semaphorin 4D (SEMA4D Antibody Abstract)
Background Semaphorins are a family of phylogeneticallyconserved soluble and transmembrane proteins. Semaphorins were originally identified as axon guidance factors during neuronal development.Semaphorins are now known to be widely expressed mediators that play significantroles in immune responses and organ morphogenesis. Sema4D (also known as CD100) is a 150-kDa transmembrane protein of the class IV semaphorin subfamily. Sema4D is expressed at high levels in lymphoid organs, including the spleen, thymus, and lymph nodes, and in non-lymphoidorgans, such as the brain, heart, andkidney. In lymphoid organs, Sema4D is expressed abundantly by T cells but weakly by B cells. Its expression is significantly enhanced inboth T and B cells, following their respective activation. Sema4D is proteolyticallycleaved from their transmembrane form to generate 120-kDa soluble forms. Two types of receptors, Plexin-B1 and CD72, have been identified for soluble Sema4D.
Gene ID 20354
Research Area Neurology
Application Notes ELISA: 1-10ug/ml. IP: 5ug/ml. FACS: 0.05ug/ml
Restrictions For Research Use only
Concentration 0.25 mg/ml
Buffer PBS [containing 2% Block Ace as a stabilizer, 0.1% Proclin as a bacteriostat]
Preservative ProClin
Storage -20 °C
Background publications Kumanogoh, Shikina, Watanabe et al.: "Requirement for CD100-CD72 interactions in fine-tuning of B-cell antigen receptor signaling and homeostatic maintenance of the B-cell compartment." in: International immunology, Vol. 17, Issue 10, pp. 1277-82, 2005 (PubMed).

Kumanogoh, Suzuki, Chng et al.: "Requirement for the lymphocyte semaphorin, CD100, in the induction of antigen-specific T cells and the maturation of dendritic cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 3, pp. 1175-81, 2002 (PubMed).

Kumanogoh, Watanabe, Lee et al.: "Identification of CD72 as a lymphocyte receptor for the class IV semaphorin CD100: a novel mechanism for regulating B cell signaling." in: Immunity, Vol. 13, Issue 5, pp. 621-31, 2001 (PubMed).

Catalog No. ABIN361535
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