KCNQ1 antibody (AA 2-101)

Catalog No. ABIN361766

The Mouse Monoclonal anti-KCNQ1 antibody is suitable to detect KCNQ1 in samples from Human. It has been validated for WB, IHC, IP, IF, ICC and AA.

Quick Overview for KCNQ1 antibody (AA 2-101) (ABIN361766)

Target: KCNQ1 (Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 1 (KCNQ1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This KCNQ1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF), Immunocytochemistry (ICC), Antibody Array (AA)

Clone: N37A-10 (Formerly S37A-10)

Product Details anti-KCNQ1 Antibody

Binding Specificity: AA 2-101

Specificity: Detects ~75 kDa.

Cross-Reactivity: Hamster, Human, Mouse, Rat

Purification: Protein G Purified

Immunogen: Fusion protein amino acids 2-101 of human KCNQ1

Isotype: IgG1

Application Details

Application Notes:

• WB (1:1000)
• IHC (1:1000)
• ICC/IF (1:100)
• optimal dilutions for assays should be determined by the user.

Comment:

1 μg/ml of ABIN361766 was sufficient for detection of KCNQ1 in 10 μg of COS-1 cell lysate transiently expressing KCNQ1 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C

Target Details for KCNQ1

Target: KCNQ1 (Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 1 (KCNQ1))

Alternative Name: KCNQ1

Background: Kv7.1 (KvLQT1) is a potassium channel protein coded for by the gene KCNQ1. Kv7.1 is present in the cell membranes of cardiac muscle tissue and in inner ear neurons (1) among other tissues. In the cardiac cells, Kv7.1 mediates the IKs (or slow delayed rectifying K+) current that contributes to the repolarization of the cell, terminating the cardiac action potential and thereby the heart's contraction (2, 3).

Gene ID: 3784

NCBI Accession: NP_000209

UniProt: P51787

Pathways: Negative Regulation of Hormone Secretion, Sensory Perception of Sound