KCNQ1 antibody

Catalog No. ABIN969227

There is 1 publication for this product available. The Mouse Monoclonal anti-KCNQ1 antibody is suitable to detect KCNQ1 in samples from Human. It has been validated for WB, ELISA and FACS.

Quick Overview for KCNQ1 antibody (ABIN969227)

Target: KCNQ1 (Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 1 (KCNQ1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This KCNQ1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Clone: 5E12

Product Details anti-KCNQ1 Antibody

Purpose: KCNQ1 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human KCNQ1 expressed in E. Coli.

Isotype: IgG2b

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-KCNQ1 antibody (ABIN969227)

Jiang, Xu, Wang, Toyoda, Liu, Zhang, Robinson, Tseng: "Dynamic partnership between KCNQ1 and KCNE1 and influence on cardiac IKs current amplitude by KCNE2." in: The Journal of biological chemistry, Vol. 284, Issue 24, pp. 16452-62, (2009) (PubMed).

Target Details for KCNQ1

Target: KCNQ1 (Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 1 (KCNQ1))

Alternative Name: KCNQ1

Background: This gene encodes a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. This protein can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome 1 (also known as Romano-Ward syndrome), Jervell and Lange-Nielsen syndrome, and familial atrial fibrillation. This gene exhibits tissue-specific imprinting, with preferential expression from the maternal allele in some tissues, and biallelic expression in others. This gene is located in a region of chromosome 11 amongst other imprinted genes that are associated with Beckwith-Wiedemann syndrome (BWS), and itself has been shown to be disrupted by chromosomal rearrangements in patients with BWS. Alternatively spliced transcript variants have been found for this gene. 

Molecular Weight: 95 kDa

Gene ID: 3784

UniProt: P51787

Pathways: Negative Regulation of Hormone Secretion, Sensory Perception of Sound