Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5) antibody

Antigen: Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5)

Synonyms: BIP, MIF2, GRP78, FLJ26106, HSPA5, DKFZp459C013, BiP, GRP-78, BiP/grp78, hspa5, MGC52648

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Mouse (Murine), Guinea Pig, Cow (Bovine), Fungus (Cryphonectria parasitica), Hamster, Monkey, Rabbit, Xenopus laevis

Application: Western Blotting (WB)

Catalog no.: ABIN361825

Additional Information

Characteristics: Detects a protein with a mass of ~78kDa corresponding to Grp78.

Alternative name: GRP78

Gene ID: NP_005338.1, 3309

Immunogen: Rat GRP78 (Bip) sythetic peptide conjugated to KLH

Format: Liquid

Description: GRP78 is a ubiquitously expressed, 78-kDa glucose regulated protein, and is commonly referred to as an immunoglobin chain binding protein (BiP). The BiP proteins are categorized as stress response proteins because they play an important role in the proper folding and assembly of nascent protein and in the scavenging of misfolded proteins in the endoplasmic reticulum lumen. Translation of BiP is directed by an internal ribosomal entry site (IRES) in the 5' nontranslated region of the BiP mRNA. BiP IRES activity increases when cells are heat stressed (1). GRP78 is also critical for maintenance of cell homeostasis and the prevention of apoptosis (2). Luo et al. have provided findings that suggest GRP78 is essential for embryonic cell growth and pluripotent cell survival (3). In terms of diseases, GRP78 has been shown to be a reliable biomarker of hypoglycemia, to serve a neuroprotective function in neurons exposed to glutamate and oxidative stress (4), and its protein levels are reduced in the brains of Alzheimer’s patients (5). Also, the induction of the GRP78 protein that results in severe glucose and oxygen deprivation could possible lead to drug resistance to anti-tumor drugs (6, 7).
Synonyms: BIP, Grp78, HspA5, MIF2, immunoglobulin heavy chain binding protein

Specificity: Detects a protein with a mass of ~78 kDa corresponding to Grp78 Species Cross-Reactivity Human, Mouse, Rat, Cow, Fungus (Cryphonectria parasitica), Hamster, Monkey, Rabbit, Xenopus

Application Details

Application Notes: Working dilution Dilution of 1:2000 for WB using ECL.

Purification: Antiserum

Storage: -20 °C

Storage Shipping Temp Max: Blue Ice or 4 °C

Research Area: Heat Shock Proteins

Restrictions: For Research Use only

Images

Grp78 (bip), rat tissue Mix, polyclonal

Grp78, rat tissues