anti-Calnexin antibody (CANX) (C-Term)

Details for Product anti-CANX Antibody No. ABIN361826
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Antigen
Synonyms zgc:63524, wu:fe06b12, clgn, clnx, cnx, CANX, CNX, IP90, P90, canx, 1110069N15Rik, AI988026, Cnx, D11Ertd153e, PP90, CG11958, Dmel\CG11958
Epitope
C-Term
(81), (25), (10), (7), (5), (5), (4), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Chicken, Cow (Bovine), Dog (Canine), Fruit Fly (Drosophila melanogaster), Guinea Pig, Hamster, Human, Monkey, Mouse (Murine), Pig (Porcine), Quail, Rabbit, Rat (Rattus), Sheep (Ovine), Xenopus laevis
(225), (119), (113), (89), (71), (69), (68), (68), (67), (66), (65), (65), (62), (38), (38), (6), (5), (4), (4), (4), (4), (4), (3), (2), (1), (1), (1)
Host
Rabbit
(198), (30), (22)
Clonality
Polyclonal
Conjugate
This Calnexin antibody is un-conjugated
(7), (7), (5), (5), (5), (5), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
(232), (136), (114), (99), (89), (74), (48), (36), (10), (8), (8), (5), (2), (1), (1), (1)
Pubmed 7 references available
Quantity 50 μL
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Immunogen Dog calnexin C-terminal synthetic peptide conjugated to KLH. Identical to human, mouse and rat calnexin sequences over these residues.
Specificity Detects the C-terminal domain of Calnexin ~90 kDa. Weak detection in Chicken, Drosophila, and Xenopus tissues
Purification Rabbit antiserum
Alternative Name Calnexin (CANX Antibody Abstract)
Background Calnexin, an abundant ~90 kDa integral protein of the endoplasmic reticulum, is also referred to as IP90, p88 and p90 (1). It consists of a large 50 kDa N-terminal calcium-binding luminal domain, a single transmembrane helix and a short acidic cytoplasmic tail (2, 3). Unlike its ER counterparts which have a KDEL sequence on their C-terminus to ensure ER retention (4), calnexin has positively charged cytosolic residues that do the same thing (3). Most ER proteins act as molecular chaperones and participate in the proper folding of polypeptides and their assembly into multi-subunit proteins. Calnexin together with calreticulin, plays a key role in glycoprotein folding and its control within the ER, by interacting with folding intermediates via their mono-glycosylated glycans (5, 6). Calnexin has also been shown to associate with the major histocompatibility complex class I heavy chains, partial complexes of the T cell receptor and B cell membrane immunoglobulin (7).
Cellular Localization: Endoplasmic Reticulum lumen | Melanosome
Gene ID 403908
NCBI Accession NP_001003232
UniProt P24643
Application Notes Recommended Dilution: WB (1:2000)
Optimal dilutions for assays should be determined by the user.
Restrictions For Research Use only
Format Liquid
Storage -20 °C
Supplier Images
anti-Calnexin (CANX) (C-Term) antibody Calnexin CT, rat tissue mix
anti-Calnexin (CANX) (C-Term) antibody (2) CalnexinCT, mouse colitis, Amplifier
anti-Calnexin (CANX) (C-Term) antibody (3) SPC108 Anti Calnexin CT, mouse backskin.jpg
Background publications Janiszewski, Lopes, Carmo et al.: "Regulation of NAD(P)H oxidase by associated protein disulfide isomerase in vascular smooth muscle cells." in: The Journal of biological chemistry, Vol. 280, Issue 49, pp. 40813-9, 2005 (PubMed).

Schrag, Bergeron, Li et al.: "The Structure of calnexin, an ER chaperone involved in quality control of protein folding." in: Molecular cell, Vol. 8, Issue 3, pp. 633-44, 2001 (PubMed).

Elagöz, Callejo, Armstrong et al.: "Although calnexin is essential in S. pombe, its highly conserved central domain is dispensable for viability." in: Journal of cell science, Vol. 112 ( Pt 23), pp. 4449-60, 2000 (PubMed).

Otteken, Moss: "Calreticulin interacts with newly synthesized human immunodeficiency virus type 1 envelope glycoprotein, suggesting a chaperone function similar to that of calnexin." in: The Journal of biological chemistry, Vol. 271, Issue 1, pp. 97-103, 1996 (PubMed).

Rajagopalan, Xu, Brenner: "Retention of unassembled components of integral membrane proteins by calnexin." in: Science (New York, N.Y.), Vol. 263, Issue 5145, pp. 387-90, 1994 (PubMed).

Tjoelker, Seyfried, Eddy et al.: "Human, mouse, and rat calnexin cDNA cloning: identification of potential calcium binding motifs and gene localization to human chromosome 5." in: Biochemistry, Vol. 33, Issue 11, pp. 3229-36, 1994 (PubMed).

Galvin, Krishna, Ponchel et al.: "The major histocompatibility complex class I antigen-binding protein p88 is the product of the calnexin gene." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 18, pp. 8452-6, 1992 (PubMed).

Validation Images
Catalog No. ABIN361826
223.30 $
Plus shipping costs $45.00
Quantity
Price
50 μL
223.30 $

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