HER2 antibody (V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian)) (pTyr1248)

Details for Product anti-ERBB2 Antibody No. ABIN362024, Supplier: Log in to see
Antigen
  • CD340
  • HER-2
  • HER-2/neu
  • HER2
  • MLN 19
  • NEU
  • NGL
  • TKR1
  • Erbb-2
  • Neu
  • c-erbB2
  • c-neu
  • mKIAA3023
  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
  • v-erb-b2 avian erythroblastic leukemia viral oncogene 2
  • v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
  • ERBB2
  • Erbb2
Alternatives
anti-Human HER2 antibody for Western Blotting
Epitope
pTyr1248
101
94
72
69
61
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55
55
48
35
26
22
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Reactivity
Human, Mouse (Murine), Rat (Rattus)
1386
501
324
36
34
15
13
8
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3
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2
1
1
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Host
Rabbit
1006
523
38
16
13
5
1
Clonality
Polyclonal
Conjugate
This HER2 antibody is un-conjugated
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9
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3
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2
Application
Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
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334
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269
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102
91
22
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19
8
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Options
Supplier
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Supplier Product No.
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Immunogen Peptide sequence around phosphorylation site of pTyr1248 (P-E-Y (p) -L-G) derived from Human HER2. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
Isotype IgG
Specificity The antibody detects endogenous level of HER2 only when phosphorylated at tyrosine1248.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removedby chromatogramphy using non-phosphopeptide corresponding to the phosphorylation site.
Alternative Name HER2 (ERBB2 Antibody Abstract)
Background Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Not activated by EGF, TGF-a and amphiregulin.
Molecular Weight 185 kDa
NCBI Accession NP_001005
UniProt P04626
Pathways RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development
Application Notes Western blotting: 1:500-1:1000
Immunohistochemistry: 1:50-1:100
Immunofluorescence: 1:100-1:200
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Product cited in: Yuan, Qian, Shi, Lu, Li, Hu, Yu, Shen, Guo: "HER2-dependent MMP-7 expression is mediated by activated STAT3." in: Cellular signalling, Vol. 20, Issue 7, pp. 1284-91, 2008 (PubMed).

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