The antibody detects endogenous level of CaMKII only when phosphorylated at threonine 286.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removedby chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Immunogen
Peptide sequence around phosphorylation site of pThr286 (Q-E-T (p) -V-D) derived from Human CaMKII. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
CAMK antibody, CAMK-II antibody, CAMKG antibody, 5930429P18Rik antibody, Camkg antibody, calcium/calmodulin dependent protein kinase II gamma antibody, calcium/calmodulin-dependent protein kinase II gamma antibody, CAMK2G antibody, Camk2g antibody
Background
CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity