CD38 antibody

Catalog No. ABIN370932

Product Details anti-CD38 Antibody

Target: CD38

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This CD38 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func)

Specificity: This antibody is specific to CD38 (Mr. 42-46 kDa). Monoclonal antibodies to CD38 have been shown to induce B- and T-cell proliferation, protect B cells from apoptosis, and inhibit B lymphopoiesis. (Ref.1-8)

Characteristics: Synonyms: cADPr hydrolase 1, T10, ADP-ribosyl cyclase 1, Cyclic ADP-ribose hydrolase 1

Endotoxin Level: Low Endotoxin

Clone: NIMR-5

Isotype: IgG2a

Application Details

Application Notes: Flow Cytometry. (Ref.1-8)Immunoprecipitation. Immunohistochemistry on Frozen Sections. (Ref.7)Functional Assay: Induction of B lymphocyte proliferation. (Ref.3-8)
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing no preservatives.

Preservative: Without preservative

Storage: -20 °C

Storage Comment: Store the antibody undiluted (in aliquots) at -20 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for CD38

Target: CD38

Abstract: CD38 Products

Synonyms: T10 antibody, Cd38-rs1 antibody, cd38 antibody, ADPRC 1 antibody, cADPr hydrolase 1 antibody, CD38 molecule antibody, CD38 antigen antibody, CD38 molecule L homeolog antibody, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 antibody, CD38 antibody, Cd38 antibody, cd38.L antibody

Background: Murine CD38, a type II transmembrane glycoprotein, is a bifunctional ectoenzyme capable of catabolizing Nicotinamide adenine dinucleotide (NAD+) to cyclic ADP-ribose (cADPR), and then hydrolyzing cADPR to adenosine diphosphoribose (ADPR). It is expressed at high levels on the surface of peripheral B-lineage cells, and at low density on germinal center B cells from unimmunized mice. It has also been reported to be expressed at moderate levels on NK cells, a proportion of peripheral T cells, and a subpopulation of thymocytes which are mostly TCRalphabeta+, CD4-, CD8-. Murine CD38 is also expressed by all Mac-1+ macrophages in the peritoneal cavities of unimmunized mice, but not by unstimulated bone-marrow-derived macrophages.Synonyms: ADP-ribosyl cyclase 1, Cyclic ADP-ribose hydrolase 1, T10, cADPr hydrolase 1

Gene ID: 12494

UniProt: P56528