T-Cell Receptor gamma/delta antibody (Biotin)

Details for Product No. ABIN371048
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Antigen
Reactivity
Mouse (Murine)
(63), (32), (10), (9)
Host
Hamster
(62), (51), (4)
Clonality (Clone)
Monoclonal ()
Conjugate
Biotin
(29), (24), (16), (5), (4), (3), (3)
Application
Flow Cytometry (FACS)
(107), (34), (31), (6), (3), (3), (1), (1), (1)
Pubmed 7 references available
Catalog no. ABIN371048
Quantity 0.5 mg
Price
346.50 $   Plus shipping costs $45.00
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Clone UC7-13D5
Isotype IgG
Characteristics Synonyms: TCRG, TCRD, T-Cell Receptor gamma, T-Cell Receptor delta, T-Cell Receptor gamma delta
Alternative Name T Cell Receptor (TCR) gamma/delta
Background T cell receptors (TCR) recognize foreign antigens which have been processed as smallpeptides and bound to major histocompatibility complex (MHC) molecules at the surfaceof antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alphaand one beta chain or one delta and one gamma chain. This region represents the germlineorganization of the T cell receptor beta locus. The beta locus includes V (variable), J(joining), diversity (D), and C (constant) segments. During T cell development, the betachain is synthesized by a recombination event at the DNA level joining a D segment with a Jsegment, a V segment is then joined to the D-J gene. The C segment is later joined bysplicing at the RNA level. The TCR gamma/delta heterodimer of the CD3/T-cell receptor complex is clonotypic andconsists of Ig-like variable and constant domains. (Ref. 1) It is expressed duringthymopoiesis and on the small subpopulation of gamma/delta TCR expressing Tlymphocytes in the periphery. The majority of T cells present in some epithelial tissues aregamma/delta+ and have limited receptor diversity. (Ref. 1,2) The TCR gamma/deltaheterodimer recognizes peptide antigen bound to MHC antigens, and subsequent signaltransduction mediated by the invariant chains leads to T cell activation. (Ref. 3)
Research Area Immunology, Receptors, Signaling
Application Notes Flow Cytometry: < / = 0.3 µg/10e6 cells. (Ref.4-7)Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.09% Sodium Azide as preservative.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or in (aliquots) at -20°C for longer. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Expiry Date 12 months
Background publications Bluestone, Cron, Barrett et al.: "Repertoire development and ligand specificity of murine TCR gamma delta cells." in: Immunological reviews, Vol. 120, pp. 5-33, 1991 (PubMed).

Allison, Havran: "The immunobiology of T cells with invariant gamma delta antigen receptors." in: Annual review of immunology, Vol. 9, pp. 679-705, 1991 (PubMed).

Barrett, Hedrick, Dent et al.: "Control of self-reactivity in the intestine." in: Immunologic research, Vol. 10, Issue 3-4, pp. 341-8, 1992 (PubMed).

Klausner, Samelson: "T cell antigen receptor activation pathways: the tyrosine kinase connection." in: Cell, Vol. 64, Issue 5, pp. 875-8, 1991 (PubMed).

Dent, Matis, Hooshmand et al.: "Self-reactive gamma delta T cells are eliminated in the thymus." in: Nature, Vol. 343, Issue 6260, pp. 714-9, 1990 (PubMed).

Davis: "T cell receptor gene diversity and selection." in: Annual review of biochemistry, Vol. 59, pp. 475-96, 1990 (PubMed).

Houlden, Matis, Cron et al.: "A TCR gamma delta cell recognizing a novel TL-encoded gene product." in: Cold Spring Harbor symposia on quantitative biology, Vol. 54 Pt 1, pp. 45-55, 1990 (PubMed).

Hosts (62), (51), (4)
Reactivities (63), (32), (10), (9)
Applications (107), (34), (31), (6), (3), (3), (1), (1), (1)
Conjugates (29), (24), (16), (5), (4), (3), (3)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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