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Integrin beta 7 antibody (ITGB7)

Details for Product anti-ITGB7 Antibody No. ABIN371134, Supplier: Log in to see
Antigen
  • Ly69
Reactivity
Mouse (Murine)
117
90
22
15
15
1
1
1
Host
Rat
72
50
16
4
2
2
Clonality (Clone)
Monoclonal ()
Conjugate
This Integrin beta 7 antibody is un-conjugated
12
12
9
5
5
5
4
4
4
3
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
Application
Functional Studies (Func), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))
79
45
30
27
17
16
11
6
5
3
2
2
1
1
1
1
Supplier
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Immunogen AKR/Cum mouse spontaneous T lymphoma cell line TK1. (Ref. 1)
Clone DATK32
Isotype IgG2a
Specificity This antibody is specific to mouse LPAM1 (Integrin alpha 4 beta 7). It recognises a conformational epitope on the heterodimer.
Characteristics Synonyms: Integrin alpha-4/beta-7, Integrin alpha 4, Integrin beta 7, ITGA4, ITGB7, LPAM1, CD49d,VLA-4, Lymphocyte Peyer PatchAdhesion Molecule
Endotoxin Level Low Endotoxin
Alternative Name Integrin beta-7 (ITGB7 Antibody Abstract)
Background The lymphocyte Peyer's patch adhesion molecule (LPAM-1), also known as Integrin alpha 4 beta 7 is a member of the integrin family of cell surface receptors. It is expressed primarily on mucosal lymphocytes, but is also present on NK cells and eosinophils. The alpha 4 beta 7 heterodimer mediates the binding of lymphocytes to its ligand, mucosal vascular addressin (MAdCAM1) on the high endothelial venules, thereby directing the homing of lymphocytes into Peyer's patches and intestinal lamina propria. (Ref.1-4)Synonyms: Adhesion Molecule, CD49d, ITGA4, ITGB7, Integrin alpha 4, Integrin alpha-4/beta-7, Integrin beta 7, LPAM1, Lymphocyte Peyer Patch, VLA-4
Gene ID 16421
UniProt P26011
Application Notes Flow Cytometry. (Ref.1-4)Immunohistochemistry on Frozen Sections. (Ref.3)Induction of homotypic cellular aggregation. Blockade of binding to cell adhesion molecules.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer PBS containing no preservatives.
Preservative Without preservative
Storage -20 °C
Storage Comment Store the antibody undiluted in (aliquots) at -20 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Expiry Date 12 months
Background publications Andrew, Rott, Kilshaw, Butcher: "Distribution of alpha 4 beta 7 and alpha E beta 7 integrins on thymocytes, intestinal epithelial lymphocytes and peripheral lymphocytes." in: European journal of immunology, Vol. 26, Issue 4, pp. 897-905, 1996

Andrew, Berlin, Honda, Yoshino, Hamann, Holzmann, Kilshaw, Butcher: "Distinct but overlapping epitopes are involved in alpha 4 beta 7-mediated adhesion to vascular cell adhesion molecule-1, mucosal addressin-1, fibronectin, and lymphocyte aggregation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 153, Issue 9, pp. 3847-61, 1994

Hamann, Andrew, Jablonski-Westrich, Holzmann, Butcher: "Role of alpha 4-integrins in lymphocyte homing to mucosal tissues in vivo." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 152, Issue 7, pp. 3282-93, 1994

Berlin, Berg, Briskin, Andrew, Kilshaw, Holzmann, Weissman, Hamann, Butcher: "Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1." in: Cell, Vol. 74, Issue 1, pp. 185-95, 1993