ABCA4 antibody

Catalog No. ABIN371821

This Mouse Monoclonal antibody specifically detects ABCA4 in WB and IHC (fro). It exhibits reactivity toward Human, Mouse, Cow and Xenopus laevis.

Quick Overview for ABCA4 antibody (ABIN371821)

Target: ABCA4 (ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4))

Reactivity: Human, Mouse, Cow, Xenopus laevis

Host: Mouse

Clonality: Monoclonal

Conjugate: This ABCA4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: 3F4

Product Details anti-ABCA4 Antibody

Specificity: This antibody reacts with ABCA4 (Rim Protein).

Cross-Reactivity (Details): Species reactivity (tested):Bovine, Human, Mouse and Xenopus.

Characteristics: Synonyms: ABCR, Stargardt disease protein, ATP-binding cassette sub-family A member 4,Retinal-specific ATP-binding cassette transporter

Purification: Protein G Chromatography.

Immunogen: Partially purified bovine 220-kDa disc rim protein.

Isotype: IgG

Application Details

Application Notes: Immunohistochemistry: 1/100. Western blotting: 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5) 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.

Storage: -20 °C

Storage Comment: Store the antibody undiluted (in aliquots) at -20 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for ABCA4

Target: ABCA4 (ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4))

Alternative Name: ABCA4

Background: ABCA4 (ATP-binding cassette, sub-family A (ABC1), member 4, Rim Protein) is a member of the superfamily of ATP-binding cassette (ABC) transporters (Illing et al., 1997). ABC proteins transport various molecules across extra- and intracellular membranes. This protein is a retina-specific ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essential molecule across the photoreceptor cell membrane. Mutations in this gene are found in patients diagnosed with Stargardt disease and are associated with retinitis pigmentosa-19 and age-related macular degeneration (Wiszniewski et al., 2003). Defects in ABCA4 are the cause of Stargardt disease type 1 (STGD1) (Molday et al., 2000). STGD is one of the most frequent causes of macular degeneration in childhood. Defects in ABCA4 are also known to cause fundus flavimaculatus (FFM), age-related macular degeneration type 2 (ARMD2) and cone-rod dystrophy type 3 (CORD3) (Klevering et al., 2005).Synonyms: ABCR, ATP-binding cassette sub-family A member 4, Retinal-specific ATP-binding cassette transporter, Stargardt disease protein

Gene ID: 24

UniProt: P78363