THRB antibody (N-Term)

Catalog No. ABIN371846

The Mouse Monoclonal anti-THRB antibody is suitable to detect THRB in samples from Human. It has been validated for WB.

Quick Overview for THRB antibody (N-Term) (ABIN371846)

Target: THRB (Thyroid Hormone Receptor, beta (THRB))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This THRB antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 2386

Product Details anti-THRB Antibody

Binding Specificity: N-Term

Specificity: This antibody is specific for the ~58k THR-beta protein.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Characteristics: Synonyms: Thyroid hormone receptor beta, THR1, NR1A2, Nuclear receptor subfamily 1 group A member2

Purification: Prepared from Mouse Ascites by Ammonium Sulfate Precipitation followed by Affinity Chromatography on Protein G.

Immunogen: Peptide corresponding to amino acid residues from the N-terminal region of human thyroidhormone receptor, beta-isotype.

Isotype: IgG1

Application Details

Application Notes: Western Blot: 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.

Storage: -20 °C

Storage Comment: Store the antibody undiluted (in aliquots) at -20 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for THRB

Target: THRB (Thyroid Hormone Receptor, beta (THRB))

Alternative Name: THRB / ERBA2

Background: Thyroid hormones are essential for development of the central nervous system and deficits in these hormones during development affects such cognitive functions as learning and memory (Ambrogini et al., 2005, Chan and Kilby, 2000). Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors TR-alpha1, TR-alpha2, TR-beta1 and TR-beta2. TR-alpha1, TR-beta1 and TR-beta2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain (Constantinou et al., 2005).Synonyms: NR1A2, Nuclear receptor subfamily 1 group A member 2, THR1, Thyroid hormone receptor beta

Gene ID: 7068

UniProt: P10828

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Sensory Perception of Sound