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THRB antibody (N-Term)

THRB Reactivity: Human, Mouse, Rat, Horse, Dog, Rabbit, Sheep WB, ChIP Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2780344
  • Target See all THRB Antibodies
    THRB (Thyroid Hormone Receptor, beta (THRB))
    Binding Specificity
    • 16
    • 7
    • 6
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 52
    • 32
    • 31
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 1
    Human, Mouse, Rat, Horse, Dog, Rabbit, Sheep
    Host
    • 50
    • 2
    • 2
    Rabbit
    Clonality
    • 52
    • 2
    Polyclonal
    Conjugate
    • 35
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This THRB antibody is un-conjugated
    Application
    • 50
    • 22
    • 15
    • 13
    • 13
    • 12
    • 7
    • 5
    • 4
    • 4
    • 3
    • 1
    Western Blotting (WB), Chromatin Immunoprecipitation (ChIP)
    Sequence
    MTPNSMTENG LTAWDKPKHC PDREHDWKLV GMSEACLHRK SHSERRSTLK
    Predicted Reactivity
    Dog: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 93%, Sheep: 93%
    Characteristics
    This is a rabbit polyclonal antibody against THRB. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human THRB
    Top Product
    Discover our top product THRB Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 461 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    THRB (Thyroid Hormone Receptor, beta (THRB))
    Alternative Name
    THRB (THRB Products)
    Synonyms
    C-ERBA-2 antibody, C-ERBA-BETA antibody, ERBA2 antibody, GRTH antibody, NR1A2 antibody, PRTH antibody, THR1 antibody, THRB1 antibody, THRB2 antibody, Nr1a2 antibody, T3R[b] antibody, T3Rbeta antibody, Thrb1 antibody, Thrb2 antibody, c-erbAbeta antibody, TR-beta antibody, TR[b]1 antibody, fj24f03 antibody, trb antibody, wu:fj24f03 antibody, CTR BETA 2 antibody, TR-BETA antibody, LOC734147 antibody, thrb antibody, THRB antibody, C-erba-beta antibody, RATT3REC antibody, T3rec antibody, TRbeta antibody, THR antibody, TRbeta1 antibody, thyroid hormone receptor beta antibody, thyroid hormone receptor, beta antibody, thyroid hormone receptor, beta S homeolog antibody, thyroid hormone receptor, beta L homeolog antibody, THRB antibody, Thrb antibody, thrb antibody, thrb.S antibody, thrb.L antibody
    Background
    THRB is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Defects in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several transcript variants have been observed for this gene, but the full-length nature of only one has been determined so far. The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene.
    Alias Symbols: ERBA-BETA, ERBA2, GRTH, MGC126109, MGC126110, NR1A2, THR1, THRB1, THRB2, PRTH, C-ERBA-2, C-ERBA-BETA
    Protein Interaction Partner: NSD1, NCOA1, RANBP9, NCOR1, RXRA, THRB, MMS19, ADAT3, NCOA2, C1D, NCOA3, ATF2, ANP32A, SUMO1, SUMO2, ROBO4, MED21, HMGN3, EIF3I, NRIP1, RXRG, RXRB, CAMK2B, TBL1XR1, NCOR2, HDAC3, SMC1A, XRCC5, TBL1X, PRKDC, LIG3, HSPA4, GPS2, XRCC6, PARP1, LRIF1, SRC, PSM
    Protein Size: 461
    Molecular Weight
    53 kDa
    Gene ID
    7068
    NCBI Accession
    NM_000461, NP_000452
    UniProt
    P10828
    Pathways
    Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Sensory Perception of Sound
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