Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5) (pSer311), (pThr315) antibody

Details for Product No. ABIN372667
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Antigen
Synonyms
Mek5, HsT17454, MAPKK5, MEK5, PRKMK5, AI324775, AI428457, Mapkk5, Prkmk5, fb73f02, wu:fb73f02, zgc:172137, ARABIDOPSIS THALIANA MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5, ATMAP2K_ALPHA, ATMEK5, ATMKK5 ... show more
Mek5, HsT17454, MAPKK5, MEK5, PRKMK5, AI324775, AI428457, Mapkk5, Prkmk5, fb73f02, wu:fb73f02, zgc:172137, ARABIDOPSIS THALIANA MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5, ATMAP2K_ALPHA, ATMEK5, ATMKK5, MAP KINASE KINASE 5, MAP kinase kinase 5, MAP2K_A show less
Epitope
pSer311, pThr315
(24), (23), (13), (12), (12), (9), (8), (7), (5), (5), (4), (3), (3), (3), (2), (2), (1), (1), (1)
Reactivity
Cow (Bovine), Dog (Canine), Chicken, Human, Mouse (Murine), Rat (Rattus), Xenopus laevis, Zebrafish (Danio rerio)
(118), (64), (58), (56), (41), (40), (24), (3), (3), (2), (1), (1), (1), (1)
Host
Rabbit
(121), (11)
Clonality
Polyclonal
Conjugate
Un-conjugated
(7), (7), (7), (5), (5), (5), (5), (5), (5), (5), (5), (2), (2), (2)
Application
Western Blotting (WB)
(82), (50), (39), (21), (13), (9), (9), (5), (3), (2), (1), (1)
Pubmed 1 reference available
Quantity 0.1 mL
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Catalog No. ABIN372667
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Immunogen Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser311, Thr315 of MEK5.
Isotype IgG
Specificity This antibody is specific for the ~49k MEK5 protein phosphorylated at Ser311, Thr315. Immunolabeling of the MEK5 band is blocked by preadsorption with the phospho-peptide used as antigen but not be the corresponding dephospho-peptide.
Purification Sequential Chromatography on phospho- and dephosphopeptide affinity columns.
Alternative Name MAP2K5
Background MEK5 (also known as MKK5) is a dual specificity serine/threonine protein kinase belonging to the MAP kinase kinase family. MEK5 has been shown to specifically activate ERK5 (Zhou et al., 1995) whereas MEK5 itself is regulated by MEKK3 (Chao et al., 1999). An important link between MEK5 and metastatic prostrate cancer has been demonstrated (Mehta et.al., 2003). Dual phosphorylation of Ser311 and Thr315 have been implicated in cell proliferation (Cameron et al., 2004).
Alternate names: Dual specificity mitogen-activated protein kinase kinase 5, MAP kinase kinase 5, MAPKK 5, MEK5, MKK5
Gene ID 29568
NCBI Accession NP_001029159
UniProt Q62862
Research Area Kinases/Phosphatases
Application Notes Western blot: 1/1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% Glycerol.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody undiluted (in aliquots) at-20°C.
Expiry Date 12 months
Supplier Images
anti-Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5) (pSer311), (pThr315) antibody anti-Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5) (pSer311), (pThr315) antibody
Background publications Zhou, Bao, Dixon: "Components of a new human protein kinase signal transduction pathway." in: The Journal of biological chemistry, Vol. 270, Issue 21, pp. 12665-9, 1995 (PubMed).

Validation Images
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