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MAPK14 antibody (Mitogen-Activated Protein Kinase 14) (pThr180)

Details for Product anti-MAPK14 Antibody No. ABIN372694, Supplier: Log in to see
Antigen
  • AP22.98
  • AP22_98
  • ATMPK14
  • mitogen-activated protein kinase 14
  • 186F5S
  • BG:DS00797.3
  • CG7393
  • D-p38
  • D-p38 MAPK
  • D-p38b
  • Dm p38b
  • Dmel\\CG7393
  • Dmp38b
  • Dp38
  • Dp38b
  • ESTS:186F5S
  • Mpk34C
  • anon-sts23
  • dp38b
  • p38
  • p38 MAPK
  • p38 beta
  • p38B
  • p38Kb
  • p38beta
  • CSBP
  • CSBP1
  • CSBP2
  • CSPB1
  • EXIP
  • Mxi2
  • PRKM14
  • PRKM15
  • RK
  • SAPK2A
  • p38ALPHA
  • Crk1
  • Csbp1
  • p38-alpha
  • p38MAPK
  • p38a
  • p38alpha
  • SAPK2a
  • CRK1
  • Csbp2
  • Exip
  • Hog
  • Prkm14
  • Prkm15
  • Sapk2A
  • p38Hog
  • csbp
  • mapk14a
  • mxi2
  • sapk2
  • sapk2a
Alternatives
anti-Dog (Canine) MAPK14 antibody for Western Blotting
Epitope
pThr180, pTyr182
28
24
17
13
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10
9
8
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7
5
5
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4
4
3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
Reactivity
Cow (Bovine), Dog (Canine), Chicken, Human, Mouse (Murine), Non Human Primates, Rat (Rattus), Zebrafish (Danio rerio)
178
80
72
17
7
7
5
3
3
2
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2
2
1
Host
Rabbit
151
30
2
1
Clonality
Polyclonal
Conjugate
This MAPK14 antibody is un-conjugated
7
7
6
5
5
5
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
163
77
53
28
23
10
10
8
7
7
4
2
1
Supplier
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Immunogen Phosphopeptide corresponding to amino acid residues surrounding the phospho-Thr180 and phospho-Tyr182 of rat p38 MAPK.
Isotype IgG
Specificity This antibody recognizes the ~39k p38 MAPK protein phosphorylated at Thr180/Tyr182. Immunolabeling is blocked by preadsorption of the antibody with the phosphopeptide used as antigen but not by the corresponding dephosphopeptide.
Cross-Reactivity (Details) Species reactivity (expected):Bovine, Canine, Chicken, Mouse, Zebrafish and non-Human Primates.
Species reactivity (tested):Human.
Purification Sequential Chromatography on phospho- and dephosphopeptide affinity columns.
Alternative Name MAP Kinase p38 alpha / MAPK14 (MAPK14 Antibody Abstract)
Background The three Mitogen-Activated Protein Kinases (MAPKs) are evolutionarily conserved protein kinases that control a vast array of cellular processes. p38 MAPK is one of these kinases and it is activated by both inflammatory cytokines and by stress (Johnson and Lapadat, 2002, Shi and Gaestel, 2002). The p38 MAPK is thought to be particularly important in diseases like asthma and autoimmunity but it also plays important roles in the stress response of the nervous system (Philip and Armstead, 2003, Ying et al., 2002). Like the other MAPKs, p38 is activated by a dual specificity kinase that phosphorylates Thr180 and Tyr182 (Lin et al., 1995).Synonyms: CSBP, CSBP1, CSBP2, CSPB1, Cytokine suppressive anti-inflammatory drug-binding protein, MAX-interacting protein 2, MXI2, Mitogen-activated protein kinase 14, SAPK2A, p38 alpha
Gene ID 1432
NCBI Accession NP_001306
UniProt Q16539
Research Area Kinases/Phosphatases
Pathways MAPK Signaling, TCR Signaling, Neurotrophin Signaling Pathway
Application Notes Western blot: 1/1000. Immunohistochemistry: 1/250-1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody undiluted (in aliquots) at-20 °C.
Supplier Images
 image for anti-MAPK14 antibody (Mitogen-Activated Protein Kinase 14) (pThr180) (ABIN372694) anti-Mitogen-Activated Protein Kinase 14 (MAPK14) (pThr180), (pTyr182) antibody
Background publications Philip, Armstead: "Differential role of PTK, ERK and p38 MAPK in superoxide impairment of NMDA cerebrovasodilation." in: Brain research, Vol. 979, Issue 1-2, pp. 98-103, 2003 (PubMed).

Johnson, Lapadat: "Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases." in: Science (New York, N.Y.), Vol. 298, Issue 5600, pp. 1911-2, 2002 (PubMed).

Shi, Gaestel: "In the cellular garden of forking paths: how p38 MAPKs signal for downstream assistance." in: Biological chemistry, Vol. 383, Issue 10, pp. 1519-36, 2002 (PubMed).

Ying, Futter, Rosenblum et al.: "Brain-derived neurotrophic factor induces long-term potentiation in intact adult hippocampus: requirement for ERK activation coupled to CREB and upregulation of Arc synthesis." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 22, Issue 5, pp. 1532-40, 2002 (PubMed).

Lin, Minden, Martinetto et al.: "Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2." in: Science (New York, N.Y.), Vol. 268, Issue 5208, pp. 286-90, 1995 (PubMed).