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Suppressor of Cytokine Signaling 1 (SOCS1) (C-Term) antibody

Details for Product No. ABIN374072
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Antigen
Synonyms socs1, zgc:91868, jab, cis1, ssi1, tip3, cish1, ssi-1, socs-1, SOCS1, LOC100228306, socs1b, CIS1, CISH1, JAB, SOCS-1, SSI-1, SSI1, TIP3, Cish1, Cish7, Socs-1
Epitope
C-Term
(30), (18), (5), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
(97), (53), (41), (14), (12), (3), (1)
Host
Goat
(96), (8), (7)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(96), (40), (22), (13), (10), (10), (9), (5), (4), (3), (3)
Pubmed 1 reference available
Quantity 0.1 mg
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Catalog No. ABIN374072
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Immunogen Synthetic peptide from the C-Terminus of Human SOCS1 (NP_003736.1). Genename: SOCS1
Sequence C-VLRDYLSSFPFQI
Specificity Recognizes Suppressor Of Cytokine Signaling 1 (SOCS1) at C-term. Species Reactivity: Tested: Human, Mouse. Expected from sequence similarity: Rat, Canine (Dog) and Bovine.
Purification Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide
Alternative Name SOCS1 / JAB
Background SOCS1 represents a family of proteins that regulates responses to cytokines. The SOCS family comprises at least 8 members, SOCS1 to SOCS7 and CIS (cytokine inducible SH2 containing protein). Structurally, the SOCS proteins are composed of an N terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C terminal motif named the SOCS box. SOCS1 (also known as Janus kinase binding protein and STAT induced STAT inhibitor 1) was isolated independently by its ability to interact with Janus kinase 2 in a 2 hybrid screen and on the basis of antigenic similarity with the SH2 domain of STAT3. SOCS 1 inhibition of signal transduction appears to occur by binding to and inhibiting the catalytic activity of members of JAK family of cytoplasmic kinases (direct JAK2 kinase inhibition). Biochemical characterization as well as gene disruption studies indicate that SOCS1 is an important negative regulator of JAK-STAT signal pathway.
Alternate names: JAB, JAK-binding protein, SOCS-1, SSI-1, SSI1, STAT-induced STAT inhibitor 1, Suppressor of cytokine signaling 1, TIP-3, TIP3, Tec-interacting protein 3
Gene ID 8651
NCBI Accession NP_003736.1
UniProt O15524
Application Notes Peptide ELISA: Limit Dilution: 1/4000. Western blot: 1-3 µg/ml. In transfected HEK293 transiently expressing human SOCS1 bandsof approx.30kDa and 25kDa are observed. These bands are not observed in thenon-transfected HEK293. A similar pattern is observed in Mouse Spleen lysates. Thecalculated molecular size is 23.6kDa according to Human NP_003736.1 and 23.7kDa
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Tris buffered saline buffer, pH~7.3 0.02% Sodium Azide 0.5% BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Supplier Images
anti-Suppressor of Cytokine Signaling 1 (SOCS1) (C-Term) antibody anti-Suppressor of Cytokine Signaling 1 (SOCS1) (C-Term) antibody
anti-Suppressor of Cytokine Signaling 1 (SOCS1) (C-Term) antibody (2) anti-Suppressor of Cytokine Signaling 1 (SOCS1) (C-Term) antibody (Image 2)
anti-Suppressor of Cytokine Signaling 1 (SOCS1) (C-Term) antibody (3) anti-Suppressor of Cytokine Signaling 1 (SOCS1) (C-Term) antibody (Image 3)
Background publications Starr, Willson, Viney et al.: "A family of cytokine-inducible inhibitors of signalling." in: Nature, Vol. 387, Issue 6636, pp. 917-21, 1997 (PubMed).

Validation Images
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